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Completed

NCT Number: NCT06538532

Anticariogenic Properties of Zamzam Water

The present study aims to evaluate and compare the effect of Zamzam water as mouthwashes in high caries-risk patients regarding:

i. Streptococcus mutans (S. mutans) count. ii. Oral pH. After 3 and 6 months interval.

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dental medicine for Girls Al Azhar university

Cairo, 4434103, Egypt

About this study

The present study aims to evaluate and compare the effect of Zamzam water mouthwashes in high caries-risk patients regarding:

i. Streptococcus mutans (S. mutans) count. ii. Oral pH. all patients will be into two groups; The first group will use Zamzam water mouthwash for a six months with other preventive protocols including fissure sealants and preventive restorations wherever needed, while the second group will undergo preventive protocols only. During these six months, patients will be reassessed at three and six-month intervals regarding S. mutans count, oral pH, and caries risk level.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female participants aged between 18-35 years.
  • Systemically- free individuals.
  • High caries-risk patients according to ADA (American Dental Association).
  • Not on a medication interfering with salivary secretion.
  • Co-operative patients approved to participate in the study.

Exclusion criteria

  • Patients who are already on any mouthwash regime.
  • Patients who are on any medication that would alter the salivary secretion.
  • Allergy to any of the ingredients of the study products.

Treatment and study plan

Zamzam water

Other

Zamzam water

Primary outcomes

  1. Streptomutans count

    Time frame: 3 months and 6 months

    measurements of Colony forming unit (CFU) will be performed using blood agar and mitis salivarius-bacitracin agar (MSBA).

  2. Salivary PH level

    Time frame: 3 months and 6 months

    using pH meter

  3. caries risk level

    Time frame: 3 months and 6 months

    According to ADA

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Effect of Zamzam Water on Streptococcus Mutans and Oral pH in High Caries-Risk Patients

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Aug 5, 2024
Registry last updated
Aug 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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