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OpenTrials
Completed

NCT Number: NCT02373111

Effects of Isoflavone Combined With Astaxanthin on Skin Aging

Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined.

Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were well-known photo-protective agents with strong antioxidant activity. Several studies have revealed that supplementation of astaxanthin effectively protect skin against UV damage through free radicals.

In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1 effectively.

The present study is designed to take isoflavone combined with astaxanthin to maximize their anti-aging ability and objectively measure the effects of the mixture on facial wrinkles, hydration, and elasticity.

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Key information

Conditions

Ageing Photo-aging

Age range

45 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Hospital

Seoul, 110744, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy females aged ≥ 45 years
  • Facial wrinkle grade 2 to 4

Exclusion criteria

  • received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study
  • received any hormone replacement therapy at least 3 months before the study
  • reported taking functional foods more than 1 month during last 3 months before the study
  • history of acute or chronic disease such as severe liver or kidney disease
  • history of allergies against any component of trial foods
  • any visible skin disease that might be confused with a skin reaction to the test procedure

Treatment and study plan

Isoflavone

Dietary Supplement

Astaxanthin

Dietary Supplement

Placebo

Dietary Supplement

Primary outcomes

  1. Change from baseline in skin wrinkles

    Time frame: Twenty-four weeks

    Facial wrinkles in the crow's feet area measured by Skin Visiometer

Secondary outcomes

  1. Change from baseline in skin elasticity

    Time frame: Twenty-four weeks

    Facial elasticity measured by Cutometer

  2. Change from baseline in epidermal hydration

    Time frame: Twenty-four weeks

    Skin hydration measured by Corneometer

  3. Change from baseline in skin barrier integrity

    Time frame: Tewnty-four weeks

    TEWL measured by Tewameter

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Feb 26, 2015
Registry last updated
Jun 14, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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