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Completed

NCT Number: NCT01930305

Effects of Heating Transfusion on Brain Function

To inversitage whether routine warming of blood is harmful to brain fuction of sugical patients receiving massive transfusion.

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Key information

Conditions

Blood Transfusion

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

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About this study

Hypothermia is an effective therapeutic intervention to reduce hypoxic ischemia brain injury in animal experiments and in clinics.In a recent study, it has been shown that perioperative warming was associated with a higher incidence of cognitive dysfunction in elderly patients.Therefore, we hypothesised that perioperative heating transfusion have a side effect on brain function of surgical patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patients scheduled for major surgery under general anesthesia and they probably need a blood transfusion during the procedure.

Exclusion criteria

•Patients with a history of stroke, central nervous system disease , metabolic disturbance, psychiatric illness, hearing impairment, drug abuse or unwilling to participate in assessment

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Treatment and study plan

Primary outcomes

  1. Brain fuction during perioperative period

    Time frame: Change from baseline at post-transfusion 15min, 30min, 1hour, 2hour, 3 hour, 6hour, 12hour, 24hour

    Brain function includes cerebral blood flow and cerebral oxygen saturation

Secondary outcomes

  1. the cognitive performance and the score of postoperative quality recovery scales ( PQRS)

    Time frame: Chang from baseline at 15min,40min,1day,3day and 7day postoperative lay

Other outcomes

  1. serum concentration of inflammatory cytokine

    Time frame: change from baseline at 3hour, 6hour, 12hour, 24hour after transfusion

Sponsors and collaborators

Lead sponsor

General Hospital of Ningxia Medical University

Other

Registry information

Official study title

Effects of Heating Transfusion on Brain Function of Surgical Patients

Important dates

Study start
2012
Primary completion
2013
Study completion
2014
First posted
Aug 28, 2013
Registry last updated
Jul 11, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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