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Completed

NCT Number: NCT06880952

Effect of Post-operative Chlorhexidine on Postoperative Pain and Complications After Surgical Removal of Mandibular Third Molars

This study aimed to assess the impact of postoperative chlorhexidine use on pain management following mandibular third molar removal

In this prospective, randomized controlled trial,130 patients who underwent mandibular third molar surgical removal were divided into two groups: one group used chlorhexidine for postoperative rinsing and the other did not rinse. Pain levels, measured using the Numeric Rating Scale (NRS), were recorded daily for the first seven days post-surgery. Paired-samples t-tests were utilized for data analysis.

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Key information

Conditions

Third Molars Extraction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Isala Hospital

Zwolle, Overijssel, 8025AB, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy adults (18+) referred by their dentist for third molar removal

Exclusion criteria

  • active pericoronitis or other infections
  • planned coronectomy
  • trismus
  • chronic pain
  • pregnancy
  • known allergies to local anesthesia

Treatment and study plan

Chlorhexidine Digluconate Mouthwash without Alcohol

Other

In the rinsing group, the patients received a bottle of 0,2% chlorhexidine

Primary outcomes

  1. Postoperative pain after removal of third molar

    Time frame: 7 days after the inclusion pain was measured on a numerical rating scale

    The primary endpoint is the difference in the postoperative pain measured on a numerical rating scale (NRS) evaluated at seven days

Secondary outcomes

  1. Post-operative complications

    Time frame: 7 days after the treatment the patient was seen at the outpatient clinic for clinical assessment. At this moment the number of patients with alveolitis, foodimpaction and bleeding was scored.

    As secondary outcome measures alveolitis, foodimpaction, bleeding or infection

Sponsors and collaborators

Lead sponsor

Isala

Other

Registry information

Official study title

Effect of Post-operative Chlorhexidine on Postoperative Pain and Complications After Surgical Removal of Mandibular Third Molars: a Randomized Controlled Trial

Acronym: RITOR

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Mar 18, 2025
Registry last updated
Mar 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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