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Completed

NCT Number: NCT02495207

A Comparison Between Conventional Surgery and Piezosurgery

Evaluation of the effect of conventional and piezo-surgery on the secretion of Heat Shock Protein (HSP70) and on the vial bone cells at the peripheral bone cut sides after the removal of impacted mandibular third molars on both sides of the jaw.

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Key information

Conditions

Third Molars Extraction

Age range

16 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Oral and Maxillofacial Surgery, University of Damascus Dental School

Damascus, Damscus, DM20AM18, Syria

About this study

The study is about measuring the amount of HSP70 using Elisa kit for detecting HSP70 and mason trichrome for histological findings in which the study samples are patients who have bilateral impacted mandibular third molar to be extracted with bone removal. First we collect bone sample for mason trichrome with either method then we collect the second samples after removing most of the bones cover the impacted third molar for checking HSP70 levels. Then the bone samples are treated using a special protocol to eliminate the protein from bone samples for the Elisa analysis. The other bone samples are going to be studied under the microscope.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • bilateral identical impacted third molar that need at least 3 mm of bone removal

Exclusion criteria

  • Pregnancy
  • Smokers
  • Infectious diseases
  • Infections around third molars (i.e. pericoronitis).
  • Alcoholic patients

Treatment and study plan

Piezosurgery

Device

This intervention is dependent on use of piezosurgery to conduct the required bone cuts to remove third molars.

Primary outcomes

  1. Levels of Heat Shock Protein 70

    Time frame: Five minutes before third molar removal with the last removed layer of bone

    This will be measured using ELISA methodology

Secondary outcomes

  1. Percentage of viable bone cells

    Time frame: This variable will be measured from the specimens taken within the first 15 minutes of bone cutting to remove third molars

    Percentage of viable bone cells will be calculated based on the counts of viable bone cells observed under the microscope.

Sponsors and collaborators

Lead sponsor

Damascus University

Other

Registry information

Official study title

A Histo-immunological Comparative Study of Bone Cutting by Conventional Surgery and Piezosurgery on the Secretion of Heat Shock Protein 70 (HSP70) and on the Bone Cells

Important dates

Study start
2014
Primary completion
2016
Study completion
2017
First posted
Jul 13, 2015
Registry last updated
Jul 27, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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