WVU Medicine Department of Orthopaedics
Morgantown, West Virginia, 26506, United States
NCT Number: NCT02638623
The investigators are testing the hypothesis that administering 2L of body temperature warmed lactated ringer's intravenously prior to surgery can optimize the postoperative and recovery of patients undergoing total hip and total knee arthroplasty.
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Notify Me18 year and older
All sexes
Interventional
Not applicable
Morgantown, West Virginia, 26506, United States
Hip and knee arthroplasty are safe and reliable surgeries for the majority of patients, but a small percentage experience major complications such as myocardial infarction, deep vein thrombosis (DVT), and pulmonary embolism (PE). As these complications are related to local tissue hypoxemia and patient immobility, interventions that can improve the ability of the heart to deliver blood to the tissue and help patients mobilize earlier in their postoperative course may decrease these complications. Based on recent evidence, it has been shown that many patients are dehydrated before surgery, which can make them feel nauseous, tired, and increase their perception of pain making them less likely to mobilize. This predisposes them to DVTs, pulmonary embolism, nausea and vomiting. Peri-operative dehydration can also decrease the ability of the lungs to oxygenate the blood properly and can place additional stress on the heart, which can increase the risk of heart attacks. The specific aim is to determine if patients' peri-operative hemodynamics can be improved with preoperative administration of 2 L of lactated ringers, and consequently reduce postoperative complications and improve recovery in arthroplasty patients.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
2L Lactated Ringer administered prior to primary knee or hip arthroplasty
No additional fluids will be administered
Other names: Saline
Time frame: 90 days post surgery
Patients found to have a 90-day postoperative complication categorized as Infection, CHF/Fluid overload, MI, DVT/PE, other
Time frame: 90 days postop
Patient readmitted to the hospital 90 day postoperatively
Time frame: Surgery to hospital discharge
Hours of Hospital Stay
Time frame: Incision to end of surgery
Minutes recorded for length of surgery
Time frame: Hospital Stay
Number of recorded emesis episodes in the medical record while patient was hospitalized
Time frame: surgical period
milliliters of fluid administered during surgery
West Virginia University
Other
Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery and Reduce Complications in Arthroplasty Patients?
Acronym: Hydration
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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