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NCT Number: NCT07296926

Distolingual Infiltration Verses Conventional Nerve Block in Mandibular Third Molar Extraction

This randomized controlled trial will compare the effectiveness of adding distolingual infiltration to conventional inferior alveolar and buccal nerve blocks for mandibular third molar extraction. A total of 120 patients will be allocated into two groups. Pain during flap elevation and bone guttering will be assessed using the Visual Analogue Scale.

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Key information

Conditions

Pain (Visceral, Somatic, or Neuropathic) Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Mandibular third molar extraction is a common oral and maxillofacial surgery procedure that requires profound local anesthesia. Despite conventional inferior alveolar, lingual and buccal nerve blocks, the distolingual gingiva may remain non-anesthetized due to accessory innervation via the mylohyoid and other nerves. Distolingual infiltration may improve anesthesia in this area.

This randomized controlled trial will enroll 120 patients requiring mandibular third molar extraction. Participants will be randomized into two groups: conventional inferior alveolar and buccal nerve block (Group A) and the same technique with additional distolingual infiltration (Group B). Pain during mucoperiosteal flap elevation and bone guttering will be recorded on a 0-10 Visual Analogue Scale. The primary objective is to determine whether distolingual infiltration improves pain control compared to the conventional technique.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy individuals
  • Male and female
  • Age 18-45 years
  • Mandibular third molar impaction - all positions
  • Mandibular third molar impaction - all classes

Exclusion criteria

  • ASA status III and above
  • Patients requiring multiple extractions in the same appointment
  • Allergy to lignocaine
  • Patients in whom adrenaline is contraindicated
  • Medically compromised individuals e.g. poorly controlled diabetes, hypertension

Treatment and study plan

Conventional Inferior Alveolar and Buccal Nerve Block

Procedure

Standard inferior alveolar and long buccal nerve block for mandibular third molar extraction.

Distolingual Infiltration plus Conventional Nerve Block

Procedure

Distolingual infiltration (0.2 ml) administered in addition to conventional inferior alveolar during mandibular third molar extraction.

Primary outcomes

  1. Pain during mucoperiosteal flap elevation

    Time frame: During mucoperiosteal flap elevation on the day of surgery

    Pain intensity experienced during flap elevation will be assessed using the Visual Analogue Scale (VAS). This is a 0-10 point numerical scale where participants indicate the pain level experienced at the time of flap elevation.

    Measurement Tool:

    Visual Analogue Scale (VAS)

    Scale:

    • Minimum score: 0 (no pain)
    • Maximum score: 10 (worst possible pain)
    • Directionality: Higher scores indicate worse pain

  2. Pain During Bone Guttering

    Time frame: During bone guttering on the day of surgery.

    Pain intensity during bone guttering will be recorded using the Visual Analogue Scale (VAS).

    Measurement Tool:

    Visual Analogue Scale (VAS)

    Scale:

    • Minimum: 0 (no pain)
    • Maximum: 10 (worst pain)
    • Higher scores = worse pain

Study contacts

Contact information is provided by the study sponsor or research team.

dr aimen zafar Aimen zafar, bds

CONTACT

[email protected]

+923361056720

Sponsors and collaborators

Lead sponsor

Watim Medical & Dental College

Other

Registry information

Official study title

Comparison of Efficacy of Distolingual Infiltration in Conjugation With Conventional Inferior Alveolar Nerve Block to Conventional Inferior Alveolar Nerve Block Alone for Extraction of Mandibular Third Molar

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Dec 22, 2025
Registry last updated
Jan 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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