Recruiting

NCT Number: NCT00001276

Diagnosing and Treating Low Blood Sugar Levels

Hypoglycemia is the term used to refer to lower than normal levels of blood sugar. This study will continue to research the causes of hypoglycemia.

Patients involved in the study will be admitted to the Clinical Center of the National Institutes of Health and undergo tests for evaluating blood sugar. Patients will be required to refrain from eating for a set period of time and will undergo blood tests for insulin levels and several other specific diagnostic tests related to insulin secretion. The patients will be under supervision and will be provided with appropriate medical and surgical attention as needed.

Recruiting

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Key information

Conditions

Hypoglycemia Adenoma Adenoma, Islet Cell Digestive System Diseases Digestive System Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Glucose Metabolism Disorders Insulinoma Metabolic Diseases Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Nutritional and Metabolic Diseases Pancreatic Diseases Pancreatic Neoplasms

Age range

18 year–120 year

Sex eligibility

All sexes

Study type

Observational

Primary location

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

Location status: Recruiting

About this study

Study Description:

The purpose of this study is to gain knowledge and experience in the diagnosis and therapy of patients with fasting hypoglycemia due to diverse etiologies, such as insulinomas. Study subjects will be evaluated and treated for their particular condition according to standard care.

Objectives:

To understand the pathophysiology and various causes of hypoglycemia (e.g., insulinomas, MEN1, MEN2).
To identify new circulating biomarkers of insulinomas.
To create a repository of clinical data and samples for future research of insulinomas.

Endpoints: None

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

Male, females ages >= 18.
Patients with documented fasting blood glucose below 55 mg/dl.

Patients with biochemical evidence for insulinoma or other pancreatic neuroendocrine tumors.

Exclusion criteria

An individual who meets any of the following criteria will be excluded from participation in this study:

Patients with significant cardiac disease will be excluded.
Subjects who are pregnant per self-report.
Medically unstable per the assessment of the PI.

Treatment and study plan

Primary outcomes

Treatment Outcomes

Time frame: every 1-3 months

resolution of hypoglycemia

Study contacts

Contact information is provided by the study sponsor or research team.

Craig S Cochran, R.N.

CONTACT

[email protected]

(301) 402-1880

Ranganath Muniyappa, M.D.

CONTACT

[email protected]

(301) 451-7702

Sponsors and collaborators

Lead sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Nih

Registry information

Official study title

Fasting Hypoglycemia: Diagnosis and Treatment

Important dates

Study start: 1991
First posted: Nov 4, 1999
Registry last updated: Jul 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed