Development of Methods for Effective Treatment and Improvement of Common Somatic Diseases in Children

Primary outcomes

1. Working with archival documentation.

   Time frame: one year

   Medical and statistical analysis of data from children's medical institutions is carried out to identify common somatic diseases in children from birth to 15 years old associated with impaired immunity.

   Evaluation criterion:

   • medical archival documentation of children's clinics in the region;
   • statistical analysis of archival documentation on the morbidity of children (acute respiratory: acute bronchitis and acute pneumonia; cardiovascular diseases: congenital heart disease, congenital and acquired carditis).

2. Formation of a group of patients to study immunity and the antioxidant system in venous blood.

   Time frame: one year

   Objective: Preparations for a clinical trial are underway.

   Work in progress:

   • 400 children with diseases of the bronchopulmonary system and congenital heart defects will be selected;
   • preparation and submission to the Ethics Committee under the Ministry of Health of Uzbekistan of all necessary documentation for the planned clinical trial among children;

   Evaluation criterion:

   • The percentage of detection of acute bronchopulmonary and congenital heart defects in the region of residence (results of medical statistics).

3. Clinical scientific research.

   Time frame: five years.

   A clinical study of sick children (acute respiratory: acute bronchitis and acute pneumonia; cardiovascular diseases: congenital heart disease, congenital and acquired carditis) is being conducted to determine the presence of immunological and antioxidant blood parameters.

   Work in progress:

   • Screening medical examination of children (objective examination, general blood test - ELISA method);
   • Examination of venous blood for indicators of immune status (extended immunogram: CD3, CD3/4, CD3/8, CD19, and others), method: flow cytometry of venous blood, mIU/mL;
   • the study of antioxidant status in sick children (Total antioxidant status, method: venous blood PCR, mmol/L);
   • publication of the research results.

   Evaluation criterion:

   • opinion of reviewers and experts in this field (comparison of the results obtained by other scientists - immunological and antioxidant research)
   • changes in immune and antioxidant status indicators in sick children to healthy peers.

4. Clinical trial evaluation.

   Time frame: three years

   The development and implementation of clinical recommendations for practicing pediatricians, pediatric pulmonologists, and cardiologists on improving children's health with acute respiratory (acute bronchitis, pneumonia) and cardiovascular (CHD, congenital and acquired carditis) diseases.

   Work in progress:

   • development and implementation of clinical recommendations for pediatricians, pediatric pulmonologists, and cardiologists;
   • assessment of the effectiveness of clinical recommendations based on repeated laboratory tests (immunological (flow cytometry, mIU/mL) and TAS (PCR, mmol/L)), after six months of implementation of the recommendations.

   Evaluation criterion:

   • opinion of reviewers and experts - review;
   • assessing the quality of life of patients (methods: PedsQLtm 4.0; HBSC), indicator: total score on the screening survey;
   • number of recurrent illnesses and complications, indicator: the number of patients as a percentage.