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Completed

NCT Number: NCT05343247

Dental Age Estimation by Different Methods in Patients With Amelogenesis Imperfecta

The aim of this study is to investigate whether there is a significant difference in dental age between children with amelogenesis imperfecta (AI) and healthy controls using Cameriere European formula and London Atlas. If there is a significant difference in dental age between children with AI and healthy controls, it is aimed to create a new formula.

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Key information

Age range

5 year–13 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Istanbul University, Faculty of Dentistry

Istanbul, Turkey (Türkiye)

About this study

One of the developmental enamel defects, amelogenesis imperfecta (AI), is also known as enamel hypoplasia/hypomineralization. It is a rare inherited disease that affects the enamel structure, amount and component in primary and permanent teeth, and it has been reported to be accompanied by some dental anomalies and nephrocalcinosis. Dental anomalies and nephrocalcinosis can affect tooth development, and there are limited studies examining tooth development in these individuals.Dental age is widely evaluated by pedodontists, forensic dentists and orthodontists. While a delay in tooth development may be associated with growth retardation and learning difficulties, dental age determination can also be used for forensic age determination for children whose birth information is uncertain. A clear assessment of maturation in children with continued growth is important in establishing a dental treatment plan.

Dental age is widely evaluated by pedodontists, forensic dentists and orthodontists. While a delay in tooth development may be associated with growth retardation and learning difficulties, dental age determination can also be used for forensic age determination for children whose birth information is uncertain. A clear assessment of maturation in children with continued growth is important in establishing a dental treatment plan.

There are two basic approaches to dental age determination in children:

  • evaluation of eruption of teeth in the oral cavity,
  • evaluation of the development and mineralization of crowns and roots on dental radiographs.

In many methods, the developmental stages of different numbers of permanent teeth are used.

One of the most widely used methods of dental age determination recently is the European formula of Cameriere et al., which is calculated based on open apex. It has been reported that this method has been tested on different population groups, and the results are accurate and reliable.

An atlas method was proposed by a group of London researchers in 2010. The Atlas shows all the teeth array images of certain age groups as a schematic series. Age determination is made by deciding which reference image matches the individual's panoramic radiography image more.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 5-13 years old
  • Healthy children
  • Children with AI
  • Patients without missing left mandibular permanent teeth on panoramic radiography

Exclusion criteria

  • Children older than 5 years old and younger than 14 years (children that cannot be assessed by the Willems and Cameriere method)
  • Poor quality panoramic radiography
  • Patients who have received orthodontic treatment
  • Patients who received restorative or endodontic treatment

Treatment and study plan

Cameriere method

Diagnostic Test

Cameriere et al. designed a quantitative approach through a formula based on sex and the ratio between length and apex opening measurements of each lower left tooth.

London Atlas method

Diagnostic Test

The London Atlas requires the user to assess the tooth development and eruption and then match it to one of the 31 pictures of age categories.

Primary outcomes

  1. Correlation coefficient of London Atlas method.

    Time frame: day 1

    Dental age of children with AI and healthy controls assessed by the correlation coefficient.

  2. Correlation coefficient of Cameriere European formula.

    Time frame: day 1

    Dental age of children with AI and healthy controls assessed by the correlation coefficient.

Secondary outcomes

  1. Dental age estimation in children with AI

    Time frame: day 1

    Dental age estimation in Turkish children

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Official study title

Evaluation of Dental Age of Children With Amelogenesis Imperfecta Using Cameriere European Formula and London Atlas

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Apr 25, 2022
Registry last updated
Aug 22, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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