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NCT Number: NCT07135063

Cranial Nerve Functions in Behçet's Disease and Their Relationship With Clinical Parameters

The goal of this study is to find out whether cranial nerves are affected in people with Behçet's Disease (BD), and how this might relate to other disease features. Cranial nerves control important functions such as vision, facial movement, hearing, swallowing, and balance.

The main questions this study will address are:

* Do people with BD have changes in cranial nerve function compared to healthy individuals? * Are these changes linked to disease duration, symptoms, or lab results?

Participants will:

* Answer questions about their medical history and BD symptoms * Complete questionnaires on daily function, mood, and autonomic symptoms * Have a clinical examination of all 12 cranial nerves * Undergo non-invasive electrical tests to assess nerve function This study will not involve any medications. All procedures will be completed in one visit.

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Key information

Conditions

Behcet Disease Behcet Syndrome Cardiovascular Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Cranial Nerve Diseases Cranial Nerve Disorder Eye Diseases Genetic Diseases, Inborn Hereditary Autoinflammatory Diseases Mouth Diseases Nervous System Diseases Panuveitis Skin Diseases Skin Diseases, Genetic Skin Diseases, Vascular Skin and Connective Tissue Diseases Stomatognathic Diseases Uveal Diseases Uveitis Uveitis, Anterior Vascular Diseases Vasculitis

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Marmara Üniversitesi Tıp Fakültesi

Istanbul, Maltepe, 34854, Turkey (Türkiye)

Location contact

General Secretary, Secretary

CONTACT

[email protected]

+90 2166254545

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aged 18-75
Diagnosed with BD according to ACR/EULAR 2013 criteria (patient group)
Healthy with no relevant medical history (control group)

Exclusion criteria

Conditions affecting CN assessment (e.g., facial trauma, surgery, radiotherapy)
Other rheumatologic or autoimmune diseases
Psychiatric disorders, alcohol/substance abuse
Pregnant women
Use of pacemakers or recent botox to masseter muscle

Treatment and study plan

Primary outcomes

Establish the presence or absence of cranial nerve involvement in BD.

Time frame: Once: Upon patient inclusion

Upon patient inclusion EMG and clinical examination is carried out

Secondary outcomes

Investigate relation between disease duration (months) and cranial nerve involvement in BD patients

Time frame: Once: Upon patient inclusion

Study contacts

Contact information is provided by the study sponsor or research team.

Mehmet Tuncay Duruöz, Professor Doctor

CONTACT

[email protected]

Reihaneh Houshyar Zarnaghi, Assistant Doctor

CONTACT

[email protected]

+90 536 507 3539

Sponsors and collaborators

Lead sponsor

Marmara University

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Aug 21, 2025
Registry last updated: Aug 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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