Correlating the Measure of Retinal Vascular Density Through Angio-OCT with Calcium Score

Recent case-control studies have proven that the retinal vascularization mirrors the cardiac vascularization: more the coronary network is altered, more the density of retinal vessels is reduced. No studies have yet been realised in primary prevention. This study aims to demonstrate a link between the density of the retinal vascularization and the calcium score, which is currently the gold standard for the classification of cardiovascular risk in primary prevention. Thus, a simple image of the retinal vascularization could predict the cardiovascular risk of a patient. OCT angiography would become a major aid in the classification of cardiovascular risk in asymptomatic patients.

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Key information

Conditions

Cardiovascular Abnormalities Cardiovascular Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Retinal Vascular Vascular Diseases

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU de Besançon

Besançon, 25000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients eligible for a calcium score as part of their standard treatment and volunteers for an ophthalmologic consultation

Exclusion criteria

Pregnant women

Treatment and study plan

Ophthalmologic consultation

Other

Complete ophthalmologic examination including angio-OCT

Primary outcomes

Correlation between retinal vascular density and calcium score

Time frame: Day 1
Comparison between values of calcium score and presence of vascular abnormalities in retina.

Calcium is scored as follows:
- Coronary Artery Calcium [CAC] = 0 : very low risk
- CAC = [1-100[ : low risk
- CAC = [100-400[ : moderate risque
- CAC = [400-1000[ : high risk
- CAC = > 1000 : very high risk

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Besancon

Other

Registry information

Acronym: ANOSCA

Important dates

Study start: 2022
Primary completion: 2023
Study completion: 2023
First posted: Nov 22, 2022
Registry last updated: Nov 18, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed