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Recruiting

NCT Number: NCT03922542

Comparison of Standard vs. Accelerated Corneal Crosslinking

The study objective is to compare accelerated and standard corneal crosslinking for treatment of progressive keratoconus or corneal ectasia.

Recruiting

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Key information

Conditions

Keratoconus Corneal Diseases Ectasia Corneal Eye Diseases

Age range

10 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

Price Vision Group

Indianapolis, Indiana, 46260, United States

Location status: Recruiting

Location contact

Francis Price, MD

PRINCIPAL_INVESTIGATOR

Marianne Price, Ph.D

CONTACT

[email protected]

317-814-2990

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Documented keratoconus or ectasia after refractive surgery

Exclusion criteria

  • Insufficient corneal thickness
  • Ocular condition that may predispose the eye to complications
  • History of chemical injury or delayed epithelial healing
  • Condition that would interfere with or prolong epithelial healing
  • Known sensitivity to treatment medications
  • Pregnancy

Treatment and study plan

riboflavin 0.1%

Combination Product

Use of riboflavin 0.1% eye drops and 9 mW/cm2 UVA light for 10 minutes

Primary outcomes

  1. Change in maximum keratometry

    Time frame: 6 months

    assessed by corneal tomography

Secondary outcomes

  1. Change in corrected distance visual acuity

    Time frame: 6 months

    assessed with Snellen chart

  2. Change in uncorrected distance visual acuity

    Time frame: 6 months

    assessed with Snellen chart

Study contacts

Contact information is provided by the study sponsor or research team.

Marianne Price, PhD

CONTACT

[email protected]

317-814-2990

Sponsors and collaborators

Lead sponsor

Price Vision Group

Industry

Registry information

Official study title

Randomized Comparison of Standard vs. Accelerated Corneal Crosslinking for Treatment of Progressive Keratoconus or Ectasia

Important dates

Study start
2019
Primary completion
2026
Study completion
2026
First posted
Apr 22, 2019
Registry last updated
Jul 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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