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NCT Number: NCT03923101

The Homburg Keratoconus Center (HKC)

Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).

The Homburg Keratoconus Center (HKC) was founded in 2010 and, up to now, comprises more than 3,000 Keratoconus patients. Topographic, tomographic and biomechanic characteristics of the disease are being analyzed with the intention to elucidate how the disease begins and develops during lifetime.

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Key information

Conditions

Keratoconus Corneal Diseases Eye Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All Keratoconus patients presenting in the department of ophthalmology, Saarland University Medical Center, Homburg, Saarland, Germany.

Exclusion criteria

  • Patients without Keratoconus.

Treatment and study plan

Topographic, tomographic and biomechanical analysis.

Diagnostic Test

The study is based upon data obtained during routine medical follow-ups using

  • the Pentacam high resolution (Oculus, Wetzlar, Germany)
  • the Corvis ST (Oculus, Wetzlar, Germany)
  • the Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2 (Tomey, Nagoya, Japan)
  • the Ocular Response Analyzer (Reichert Technologies, New York, USA).

Primary outcomes

  1. An overview about development of anterior corneal curvature in Keratoconus disease during lifetime.

    Time frame: 01/01/2011-01/01/2019

    The anterior radius of curvature (ARC, 3mm zone) of Keratoconus patients as measured by the Pentacam high resolution (Oculus, Wetzlar, Germany) at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.

  2. An overview about development of posterior corneal curvature in Keratoconus disease during lifetime.

    Time frame: 01/01/2011-01/01/2019

    The posterior radius of curvature (PRC, 3mm zone) of Keratoconus patients as measured by the Pentacam high resolution (Oculus, Wetzlar, Germany) at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.

  3. An overview about development of the thinnest corneal pachymetry in Keratoconus disease during lifetime.

    Time frame: 01/01/2011-01/01/2019

    The thinnest corneal pachymetry of Keratoconus patients as measured by the Pentacam high resolution (Oculus, Wetzlar, Germany) at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.

  4. An overview about development of the best corrected distance visual acuity in Keratoconus disease during lifetime.

    Time frame: 01/01/2011-01/01/2019

    The best corrected distance visual acuity of Keratoconus patients as raised as part of the clinical examination at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.

  5. Reproducibility study: Kmax.

    Time frame: 01/01/2011-01/01/2019

    Measurements of Kmax measured by different devices (Pentacam high resolution, Oculus, Wetzlar, Germany; Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2, Tomey, Nagoya, Japan) are being compared and set into relation at different Keratoconus stages with the intention to investigate, whether measurement inaccuracies occur at later Keratoconus stages using different devices.

  6. Reproducibility study: Thinnest corneal pachymetry.

    Time frame: 01/01/2011-01/01/2019

    Measurements of the thinnest corneal pachymetry as measured by different devices (Pentacam high resolution, Oculus, Wetzlar, Germany; Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2, Tomey, Nagoya, Japan) are being compared and set into relation at different Keratoconus stages with the intention to investigate, whether measurement inaccuracies occur at later Keratoconus stages using different devices.

  7. Reproducibility study: Thinnest corneal pachymetry at the apex position.

    Time frame: 01/01/2011-01/01/2019

    Measurements of the thinnest corneal pachymetry at the apex position as measured by different devices (Pentacam high resolution, Oculus, Wetzlar, Germany; Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2, Tomey, Nagoya, Japan) are being compared and set into relation at different Keratoconus stages with the intention to investigate, whether measurement inaccuracies occur at later Keratoconus stages using different devices.

Sponsors and collaborators

Lead sponsor

Universität des Saarlandes

Other

Registry information

Official study title

The Homburg Keratoconus Center (HKC) - a Keratoconus Observation Study

Important dates

Study start
2011
Primary completion
2036
Study completion
2036
First posted
Apr 22, 2019
Registry last updated
Apr 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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