Comparison of Sevoflurane, Propofol, and Sevoflurane Plus Propofol for Maintenance of Anaesthesia

After approval from the Institute's Ethics Committee, this study was conducted at Tongji Hospital, a general university teaching hospital with 2500 beds in Wuhan, China.The study consisted of female patients, American Society of Anaesthesiologists Physical Status (ASA-PS) I or II, suffering from infertilities, and undergoing selective gynaecological laparoscopic and hysteroscopic surgery. All the patients were randomly assigned to receive propofol,sevoflurane,or sevoflurane+propofol for anaesthesia maintenance. The primary outcome measure was the level of postoperative pain assessed by Numerical Analogue Scale (NAS) at rest 0.5 hour after the operation. The secondary outcomes were postoperative pain assessed by Numerical Analogue Scale (NAS) at rest 1 and 24 hour after the operation, the incidence of postoperative nausea and vomiting, the incidence of shiver, and quality of recovery determined by QOR40 in the first 24 h after surgery.

Inclusion criteria

• ASA physical status class 1 or 2
• Aged >=18 years and =<40 years old
• Suffering from infertilities
• Under elective gynaecological laparoscopic and hysteroscopic surgery

Exclusion criteria

• ASA-PS>=III
• Aged under 18 yrs or above 40 yrs old
• Body mass index (BMI) >30
• Respiratory or Neurologic disease
• Chronic antidepressants and Anticonvulsant drugs
• Chronic analgesics intake
• A known allergy to the drugs being used
• History of substance abuse
• Participating in the investigation of another experimental agent
• Participating in the investigation of another study