Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07583433

Maneuvers to Reduce Laparoscopic Pain

Laparoscopic surgery has revolutionized surgical care by reducing morbidity and improving post operative recovery. Laparoscopic surgery involves the use of carbon dioxide for insufflation to achieve optimal visualization. There is literature that demonstrates higher insufflation pressures being associated with increased postoperative pain - particularly shoulder pain - and opioid use. The ideal amount of intraperitoneal pressure is still under debate as other studies demonstrate that reduced pneumoperitoneum insufflation has also shown to negatively impact surgeon satisfaction and trended with longer operative time and greater blood loss without impacting pain.

Residual intraperitoneal carbon dioxide can also contribute to postoperative discomfort. Studies have shown the effectiveness of various maneuvers in removing residual gas to reduce postoperative pain, such as intraperitoneal saline instillation, pulmonary recruitment, and gas aspiration via smoke evacuator.

Despite these advantages, there is a lack of a clear consensus on the optimal method for reducing residual intraperitoneal gas. Conversely, literature has mixed results regarding the true significance in pain reduction.

Given the importance of minimizing postoperative pain, reducing opioid requirements, and shortening postoperative recovery time, the investigators propose a prospective, patient-blinded, randomized controlled trial. The investigators aim to investigate whether active gas removal via a smoke evacuator, multiple breath recruitment maneuvers, or no intervention would contribute to lowest postoperative pain. The findings will help identify the most effective method for reducing residual pneumoperitoneum-related pain and thus inform surgical practices and improve patient outcomes.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Henry Ford Hospital

Detroit, Michigan, 48202, United States

Location contact

Ilinca Lupea, MD

CONTACT

[email protected]

313-425-4567

Ilinca Lupea, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients age 18 to 65
  • Benign, elective laparoscopic surgeries

Exclusion criteria

  • Ages <18 and age >65
  • Emergency or urgent surgeries
  • Surgeries for chronic pelvic pain, malignancy
  • Surgeries during pregnancy
  • Severe cardiopulmonary disease
  • Prior extensive abdominal surgeries (more than 2 abdominal or pelvic surgeries)
  • Inability to consent

Treatment and study plan

Smoke Evacuation Group

Procedure

Active gas removal via smoke evacuator for 30 seconds at the end of case.

Recruitment Breath Group

Procedure

Repeated pulmonary inflation maneuvers: Three (3) consecutive manual ventilations at maximum of 30 cm water at the end of case.

Control Group

Procedure

Passive desolation of the pneumoperitoneum at the end of the laparoscopic surgery.

Primary outcomes

  1. Post operative pain

    Time frame: From enrollment until 1 week post surgery

    Post-operative pain: Patients will be assessed using the Numeric Rating Scale (NRS) by rating their pain on a scale from 0 (no pain) to 10 (worst pain imaginable) immediately prior to leaving the post-anesthesia care unit, on post-operative day 2, and post-operative day 7.

Secondary outcomes

  1. Opioid use for the management of post operative pain

    Time frame: Time of enrollment until their post operative appointment up to 2 weeks from the time of surgery

    Opioid use: Patients will be asked how many of the opioid pain medication pills they were discharged with were consumed, at either their 2-week post-operative in-person visit or phone call question. Patients will be instructed to either count the number of pills that were taken or bring the bottle to their visit.

Sponsors and collaborators

Lead sponsor

Henry Ford Health System

Other

Registry information

Official study title

Optimal Maneuver to Reduce Postoperative Pain Following Elective Laparoscopic Surgeries

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
May 13, 2026
Registry last updated
Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.