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OpenTrials
Completed

NCT Number: NCT06065956

Comparison of Hemodynamic Changes With Morphine Versus Esmolol During Induction of Anaesthesia

Comparing hemodynamic changes with morphine versus esmolol as an adjuvant agent during induction of Anaesthesia

Completed

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Key information

Conditions

Intubation Complication

Age range

25 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

PNS Shifa Hospital

Karachi, Sindh, 46000, Pakistan

About this study

Comparing hemodynamic profile of patients during induction of General Anesthesia with intravenous morphine as an adjuvant drug versus Intravenous esmolol as an adjuvant agent,My aim is to study which drug has superior hemodynamic profile in terms of hemodynamic stability of patient requiring General Anesthesia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA 2 patients presenting for elective surgery.

Exclusion criteria

  • Patients having major cardiac disease.
  • Metastatic disease.
  • Pregnant females.
  • Those unwilling to be part of study.

Treatment and study plan

intravenous morphine

Drug

Morphine group(an opioid), participants were given intravenous morphine(an opioid) at induction of General Anaesthesia before laryngoscopy and intubation.

The other group,Esmolol group(cardioselective beta blocker), participants were given intravenous esmolol(cardioselective beta blocker) during induction of General Anesthesia before laryngoscopy and intubation.

Other names: Intravenous esmolol

Primary outcomes

  1. Blood pressure

    Time frame: 06 months

    Change in blood pressure between baseline value and post Intubation value will be measured in millimeter of mercury (mmHg).

  2. Pulse rate

    Time frame: 06 months

    Change in pulse rate between baseline value and post intubation value will be measured per minute.

Sponsors and collaborators

Lead sponsor

Pakistan Navy Station Shifa Hospital

Other

Registry information

Official study title

Comparison of Hemodynamic Changes With Morphine Versus Esmolol as an Adjuvant Agent During Induction of Anaesthesia

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Oct 4, 2023
Registry last updated
Oct 4, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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