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Completed

NCT Number: NCT07125495

The Effect of an Suction Toothbrush on the Development of Ventilator-Associated Pneumonia

Literature suggests that suction toothbrushes may improve oral care in intubated patients by facilitating secretion removal and reducing microaspiration. This could decrease the need for endotracheal suctioning and lower the risk of ventilator-associated pneumonia (VAP). Therefore, this study aimed to examine the effect of a suction toothbrush on the development of VAP in intubated patients.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Koç University hospital Intensive care unit

Istanbul, 34010, Turkey (Türkiye)

About this study

in the literature examining the superiority of a suction toothbrush over another regarding the frequency of oral care practices, appropriate solution and material use in intubated patients. It is believed that a suction toothbrush will both facilitate oral care and clear oral secretions. By minimizing secretion accumulation in the mouth, it will prevent microaspiration and reduce the need for endotracheal suctioning in patients. Determining the most effective oral care method is expected to reduce the incidence of ventilator-associated pneumonia and positively impact patient mortality. Considering all this information, the aim of this study was to examine the effect of a suction toothbrush on the development of ventilator-associated pneumonia in intubated patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients

  • who aged over 18 years
  • who underwent orotracheal intubation after admission to the ICU,
  • who had no known pneumonia or diagnosis of pneumonia at the time of intubation,
  • who were intubated for more than 48 hours,
  • who had no microorganisms detected in the tracheal aspirate within the first 48 hours,
  • who had no lesions on the oral mucous membrane before intubation,
  • who had no known allergy to chlorhexidine were included in the study.

Exclusion criteria

Patients

  • who under 18 years of age,
  • those with a tracheostomy,
  • those were intubated for less than 48 hours,
  • those with microorganisms detected in their tracheal aspirate within the first 48 hours,
  • those who underwent reintubation,
  • those were pregnant,
  • those with lesions in the oral mucosa during intensive care admission,
  • those with bleeding coagulation disorders or thrombocytopenia,
  • those admitted to intensive care from an external institution while intubated, and those with a known chlorhexidine allergy were excluded from the study.

Treatment and study plan

Suction tootbrush and distiled water

Other

All tooth surfaces, oral mucosa, and the tongue and surrounding area were cleaned every 8 hours (3x1) with distilled water and a suction toothbrush. The aspiration feature of the suction toothbrush enabled oral care and simultaneous aspiration of oropharyngeal secretions.

suction tootbrush and .12% chlorhexidine gluconate

Other

Every 8 hours (3x1) 15 ml of 0.12% chlorhexidine gluconate oral solution (Adıgüzel, 2015) will be used with a suction toothbrush to clean all tooth surfaces, the oral mucosa, and the tongue. The aspiration feature of the suction toothbrush allows for the aspiration of oropharyngeal secretions during oral care.

Oral care sponge and with 15 ml of 0.12% chlorhexidine gluconate oral solution

Other

All tooth surfaces, oral mucosa, and the tongue and surrounding tongue were cleaned with 15 ml of 0.12% chlorhexidine gluconate oral solution (Adıgüzel, 2015) every 8 hours (3x1) and an oral care sponge used in oral care in the intensive care unit. After oral care, oropharyngeal secretions were aspirated.

Primary outcomes

  1. The ventilatory associated pneumonia (VAP)

    Time frame: Patients were included 48 hours after admission to the intensive care unit and intubation. After 48 hours of intubation, the development of VAP will be considered as a positive.

    The development of ventilator-associated pneumonia (VAP) after entubation in the intensive care unit (Yes / no). If a patient presents signs and symptoms of VAP with both clinical Findings and laboratory findings, researchers will diagnose it as a VAP.

Sponsors and collaborators

Lead sponsor

Koç University

Other

Collaborators

  • Koc University Hospital

Registry information

Official study title

The Effect of an Suction Toothbrush in Intubated Intensive Care Patients on the Development of Ventilator-Associated Pneumonia: A Randomized Controlled Trial

Acronym: Toothbrush

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 15, 2025
Registry last updated
Apr 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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