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Completed

NCT Number: NCT02679222

Comparing the Ketogenic Effect of Coconut Oil and Different MCTs

The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults. Each oil are evaluated individually or in combination over a 8h-period during which repeated blood sampling is performed.

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Key information

Conditions

Healthy Adults Acid-Base Imbalance Acidosis Ketosis Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)

Sherbrooke, Quebec, J1H4C4, Canada

About this study

The study is composed of eight successive visits. Each visit consists of the consumption of one individual oil or a mixture of oils (20 g of coconut oil or 10 g of coconut oil + 10 g of MCT 60-40 or 20 g MCT 60-40 or 10 g coconut oil + 10 g tricaprylin or 20 g tricaprylin or 10 g coconut oil + 10 g triheptanoate or 20 g triheptanoate) and a 8h follow-up during which repeated blood samples are taken for laboratory analysis (plasma beta-hydroxybutyrate, acetoacetate, glucose, free fatty acids, triglycerides, total cholesterol, lactate and insulin).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adult over 18 y old.

Exclusion criteria

  • Fasting plasma glucose ≥7.0 mM (diabetics or pre-diabetics);
  • Smoking
  • Clinically-significant gastro-intestinal disease/conditions.
  • Clinically-significant liver disease/dysfunction.
  • Clinically-significant cardiac disease/conditions.
  • Clinically-significant abnormal coagulation.
  • Taking a medication that could affect lipid and glucose metabolism
  • Hypertension
  • Pregnancy or breastfeeding
  • Exercising more than 3 times a week

Treatment and study plan

Coconut oil

Dietary Supplement

20 g of coconut oil

Other names: Coco

Coconut oil + MCT

Dietary Supplement

10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10)

Other names: Coco+MCT

MCT

Dietary Supplement

20 g of MCT (60 of C8+40 of C10)

Coconut oil + tricaprylin

Dietary Supplement

10 g coconut oil + 10 g tricaprylin

Other names: Coco+C8

Tricaprylin

Dietary Supplement

20 g tricaprylin

Other names: C8

Tricaprin

Dietary Supplement

20 g tricaprin

Other names: C10

Control

Dietary Supplement

No supplement taken on this visit

Other names: CTL

Primary outcomes

  1. Plasma Ketone Concentrations

    Time frame: 8 hours

    Total ketones = Plasma acetoacetate (µmol/L) + beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e. daily mean).

    Samples are taken every 30 minutes on a 8 hours period. The mean is reported here.

Secondary outcomes

  1. Plasma Acetoacetate/Beta-hydroxybutyrate Ratio

    Time frame: 8 hours

    Plasma ratio of acetoacetate (µmol/L)/ beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e area-under-the-curve over 8 hours).

Sponsors and collaborators

Lead sponsor

Université de Sherbrooke

Other

Registry information

Official study title

Comparing the Ketogenic Effect of Coconut Oil and Different Medium-chain Triglycerides

Acronym: MCT-Coco

Important dates

Study start
2015
Primary completion
2016
Study completion
2017
First posted
Feb 10, 2016
Registry last updated
Apr 6, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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