Skip to main content
OpenTrials
Completed

NCT Number: NCT02693106

Evaluation of the Ketogenic Potential of Different Diet Supplements

Evaluate the capacity of different dietary supplements to increase ketone production in healthy adults.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy Adults Acid-Base Imbalance Acidosis Ketosis Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)

Sherbrooke, Quebec, J1H4C4, Canada

About this study

The aim of this study is to evaluate the capacity of different dietary supplements to increase ketone production in healthy adults. Each supplement (leucine, butyrate, octanoate, carnitine or butter fraction rich in MCT) is evaluated for a period of 4-hour during which multiple blood samples are taken in order to measure ketone production.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults aged of 18 years old or older.
  • Non-smoking.

Exclusion criteria

  • Diabetes or prediabetes
  • Uncontrolled hypertension
  • Uncontrolled thyroid function
  • Taking medication that will affect lipid/glucose metabolism
  • Severe infection or inflammation
  • Pregnancy

Treatment and study plan

Control

Dietary Supplement

Visit corresponding to a standardize breakfast taken alone (control visit) followed by a period of 4-hour with multiple blood sampling.

Other names: CTL

Leucine

Dietary Supplement

Visit corresponding to a standardize breakfast with 5 g of leucine followed by a period of 4-hour with multiple blood sampling.

Butyrate -

Dietary Supplement

Visit corresponding to a standardize breakfast with 3.6 g of butyrate followed by a period of 4-hour with multiple blood sampling.

Butyrate +

Dietary Supplement

Visit corresponding to a standardize breakfast with 7.2 g of butyrate followed by a period of 4-hour with multiple blood sampling.

Octanoate -

Dietary Supplement

Visit corresponding to a standardize breakfast with 5 g of octanoate followed by a period of 4-hour with multiple blood sampling.

Octanoate +

Dietary Supplement

Visit corresponding to a standardize breakfast with 10 g of octanoate followed by a period of 4-hour with multiple blood sampling.

carnitine

Dietary Supplement

Visit corresponding to a standardize breakfast with 1.95 g of carnitine followed by a period of 4-hour with multiple blood sampling.

Butter fraction

Dietary Supplement

Visit corresponding to a standardize breakfast with 65 g of butter fraction followed by a period of 4-hour with multiple blood sampling.

Primary outcomes

  1. Concentration of Total Plasma Ketones

    Time frame: 4 hours

    Difference from Time 0 in Total ketones = acetoacetate (umol/L) + beta-hydroxybutyrate (umol/L) Time 0 is when the participants arrived, after a 12 hours fast, i.e. before the breakfast.

    Plasma was collected every 30 minutes for 4 hours immediately following breakfast (where supplements were taken).

    Results are the mean of plasma ketones measured every 30 minutes ( i.e. total of 9 plasma samples) for the 4 hour period.

    For each time point, the difference form time 0 has been made. So this is the mean of the difference from time 0 in total ketones.

    Data were not collected for the 'Intervention 8: 65 g of butter fraction rich in MCT' supplement.

Sponsors and collaborators

Lead sponsor

Université de Sherbrooke

Other

Registry information

Official study title

Stimulating the Ketogenesis by Using Nutritional Supplements

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Feb 26, 2016
Registry last updated
Mar 25, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.