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NCT Number: NCT04935164

Comparative Study of Gender Identity Disorder Versus Control

Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity.

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Key information

Conditions

Gender Dysphoria, Adult Gender Dysphoria Mental Disorders Sexual Dysfunctions, Psychological

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier Henri Laborit

Poitiers, 86021, France

Location status: Recruiting

Location contact

Bérangère Thirioux, PhD

CONTACT

[email protected]

About this study

Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity. Gender dysphoria is accompanied by the often overwhelming need for a hormonal or even hormone-surgical transition. Gender dysphoria is very often characterized by fluctuating mood sadness, irritability, obsessionality. An improvement in the quality of life after medical treatment (hormone therapy) and gender reassignment surgery has been described in the literature. Morphological similarities have been found between the brains of women and the brains of so-called transgender women, as well as between the brains of transgender men and men. These morphological data are only very fragmentary and have not been supported by neuro-functional data. Self-awareness, which refers to the awareness that an individual has of his body, his image and his own identity, is partly underpinned, at the brain level, by the activation of the Default Mode Network (DMN) at rest, in non-pathological conditions. The conflict between the internal perception of the own body and its objective representation could result in a change in brain connectivity within the DMN, due in particular to changes in the activation of the temporo parietal junction.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with gender dysphoria
  • Without psychotropic
  • Without hormono-therapy
  • Without sexual surgery assignation

Exclusion criteria

  • Any depression
  • Any addiction

Treatment and study plan

Psychiatric evaluations

Other

At different time points, several psychiatric evaluations will be performed on patients and volunteers for study purposes

Other names: Electroencephalography, Double Mirror Test, Mini International Neuropsychiatric Interview, Montgomery-Åsberg Depression Rating Scale, Hamilton Rating Scale for Depression

Primary outcomes

  1. Contribution of temporal parameters of microstates C, D, E and F

    Time frame: Week 1 to Week 24

    The proportion of the total time spent in microstates of class C,D,E and F

  2. Duration of temporal parameters of microstates C, D, E and F

    Time frame: Week 1 to Week 24

  3. Mean-Global Field Power temporal parameters of microstates C, D, E and F

    Time frame: Week 1 to Week 24

  4. Occurrence of temporal parameters of microstates C, D, E and F

    Time frame: Week 1 to Week 24

  5. Cortical voxel activity from source reconstruction analysis, using electroencephalogram during Double Mirror Test (D.M.T).

    Time frame: Week 1 to Week 24

Study contacts

Contact information is provided by the study sponsor or research team.

Bérangère Thirioux, PhD

CONTACT

[email protected]

0033 5 49 44 58 56

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Henri Laborit

Other

Registry information

Official study title

Comparative Study of Gender Dysphoria Phenomenology and Neurophysiology: Clinical and Experimental Exploration of Gender Identity Disorder

Acronym: TRANSIDENT

Important dates

Study start
2021
Primary completion
2029
Study completion
2029
First posted
Jun 22, 2021
Registry last updated
Jun 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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