Comparative Assessment of Mental/Incisive and Inferior Alveolar Nerve Block Anesthesia in Root Canal Treatment of Mandibular Premolars

The goal of this clinical trial is to systematically compare the pain scores and anesthesia efficacy of IANB and MNB in the treatment of symptomatic mandibular first and second premolars. This study aims to address gaps in current evidence and clarify whether these anesthesia techniques differ in effectiveness and patient experience during endodontic procedures. The hypotheses include: (i) no difference in pain perception between IANB and MNB, (ii) no difference between first and second premolars with IANB, and (iii) no difference between first and second premolars with MNB.

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Key information

Conditions

Mandibular Nerve Aortic Valve Disease Bicuspid Aortic Valve Disease Cardiovascular Abnormalities Cardiovascular Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Heart Defects, Congenital Heart Diseases Heart Valve Diseases Mandibular Nerve Blocks Mental Nerve Block Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Premolars Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cukurova University Dentistry Faculty Department of Endodontics Clinic

Adana, 01380, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Individuals classified as ASA 1 or ASA 2.
Age range of 18 to 65 years.
No known allergies to articaine or epinephrine.
Absence of facial paresthesia.
No use of analgesic medications within 6 hours prior to treatment.
No use of medications, such as tricyclic antidepressants or beta blockers, that may interfere with anesthesia.
No pathological conditions at the planned injection site.
Periodontal pocket depth of 3 mm or less.
Mandibular first or second premolars diagnosed with symptomatic irreversible pulpitis.
Teeth meeting Glickman's gingival health criteria upon periodontal examination.
Radiographically closed root apex with no detectable pathology.
Patients must be literate and able to comprehend the use of a pain scale to provide informed consent voluntarily.

Exclusion criteria

Presence of systemic conditions contraindicating endodontic treatment. Age below 18 or above 65 years.
Pregnancy.
Documented allergy to articaine with 1:100,000 epinephrine.
Evidence of periapical pathology or radiolucency observed in radiographs.
Recent use of central nervous system depressants or analgesic medication within 6 hours prior to treatment.
Absence of reported lip numbness 10 minutes following IANB or MINB injection. Presence of a large restoration on the affected tooth.

Treatment and study plan

inferior alveolar nerve block with 4% articaine

Other

A single ampoule of 4% articaine was administered to a cohort of patients presenting with irreversible pulpitis in the first or second mandibular premolars, designated for Inferior Alveolar Block anesthesia via the mandibular foramen.

Mental/Incisive Nerve Block (%4 Articaine)

Other

A single ampoule of 4% articaine was administered to a cohort of patients presenting with irreversible pulpitis in the first or second mandibular premolars, designated for Mental or Incisive Nerve Block anesthesia via the mental foramen.

Primary outcomes

Numerical Rating Scale

Time frame: Following anesthesia administration, a 10-minute waiting period was observed. Patients completed a Numerical Rating Scale immediately upon initiation of the endodontic cavity procedure and again after the start of pulp extirpation.

The patients were asked to rate the pain experienced during endodontic access cavity preparation and pulp extirpation using a Numerical Rating Scale. The Numerical Rating Scale was printed on A4 paper, scaled to fit horizontally, with values from 0 to 10 displayed along a bar. The Numerical Rating Scale uses a 0 to 10 scale, with increments of one unit. Patients were instructed to mark '0' if they experienced no pain, select a value between "1" and "3" for mild pain, a value between "4" and "6" for moderate pain, and a value between "7" and "10" for severe pain.

Sponsors and collaborators

Lead sponsor

Cukurova University

Other

Registry information

Official study title

Anesthetic Effectiveness of Mental/incisive Nerve Block Versus Inferior Alveolar Nerve Block in Mandibular I. and II. Premolars with Symptomatic Irreversible Pulpitis: a Randomized Clinical Trial

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2024
First posted: Nov 7, 2024
Registry last updated: Nov 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed