NCT Number: NCT03851289
Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation
This study evaluated the effectiveness of socket grafting material, combination of plate-rich fibrin and calcium sulfate. 5 subjects were grafted with this material, 5 subjects were grafted with combination of plate-rich fibrin and xenograft.
Looking for future studies?
Notify MeKey information
Conditions
Age range
25 year–55 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
About this study
Calcium sulfate (CS), an alloplastic material, is widely accepted as a socket grafting material and undergoes rapid and complete resorption. Studies have shown that CS creates an osteoconductive lattice that stimulates bone ingrowth into a defect. PRF poses multiple growth factors, anti-inflammatory cytokines and adhesion molecules. It is biologically active up to one week. The combination of these 2 materials will serve as good grafting material for tooth socket, in order to preserve vertical and horizontal dimensions.
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- maxillary premolar teeth requiring extraction
- neighboring mesial and distal sound/restored teeth present
- alveolar bone level (measured from periapical radiographs) more than 50% of the root length
- age ranges from 25-55 years
Exclusion criteria
- bony fenestration of the socket wall confirmed from CBCT scan
- acute signs of infection
- periodontally compromised teeth
- absence of buccal plates
- any systemic disease which may hinder the healing process
Treatment and study plan
platelet-rich fibrin and xenograft
Combination ProductPrimary outcomes
-
vertical dimension at baseline
Time frame: before extraction
measurements were done on radiograph (CBCT) images
-
horizontal dimension at baseline
Time frame: before extraction
measurements were done on radiograph (CBCT) images
-
soft tissue level at baseline
Time frame: before extraction
measurements were done on stone models
-
volume at baseline
Time frame: before extraction
measurements were done on radiograph (CBCT) images
Secondary outcomes
-
vertical dimension after extraction
Time frame: five months after extraction
measurements were done on radiograph (CBCT) images
-
horizontal dimension after extraction
Time frame: five months after extraction
measurements were done on radiograph (CBCT) images
-
soft tissue level after extraction
Time frame: five months after extraction
measurements were done on stone models
-
volume after extraction
Time frame: five months after extraction
measurements were done on radiograph (CBCT) images
Sponsors and collaborators
Lead sponsor
University of Malaya
Other
Registry information
Important dates
- Study start
- 2016
- Primary completion
- 2017
- Study completion
- 2018
- First posted
- Feb 22, 2019
- Registry last updated
- Mar 25, 2020
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Related clinical trials
Published trials that share one or more normalized conditions with this study.
Evaluation of Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials
NCT07725029
Tooth Extraction
Al Mansurah, Egypt
View Trial DetailsThe Impact of the Objective Structured Clinical Examination
NCT07664917
Education, OSCE (Objective Structured Clinical Examination)
Kirikkale, Yahşihan, Turkey (Türkiye)
View Trial DetailsBMP Effect on Implant Stability and Marginal Bone Level After Immediate Placement
NCT07240493
Alveolar Ridge Resorption After Extraction, Mouth Diseases
Baghdad, Baghdad Governorate, Iraq
View Trial DetailsPlasma Rich in Growth Factors in Post-extraction Sockets
NCT03943680
Dental Implants, Tooth Extraction
Granada, Spain
View Trial Details