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Completed

NCT Number: NCT07725029

Evaluation of Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials

Thirty two healthy patients will be selected from the outpatient clinic of the oral and maxillofacial surgery department, faculty of dentistry, Mansoura university, to be included in this study with non restorable teeth in the maxillary esthetic area. After atraumatic teeth extraction, immediate implant placement will be done and buccal jumping gap will be filled by demineralized dentin matrix in study group and control one by demineralized dentin matrix mixed with in injectable platelet rich fibrin.

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Key information

Conditions

Tooth Extraction

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mansoura

Al Mansurah, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient age ranged between 18-40 years old.
  • Patients seeking to replace non-restorable tooth / teeth in maxillary esthetic zone (anterior &premolars) by using immediate implant placement.
  • Cooperative patients with high motivation and good oral hygiene.
  • Intact socket wall after tooth extraction.
  • Jumping gap more than 2mm.
  • Favorable occlusion without presence of parafunctional habits, eg; bruxism and clenching.
  • Sufficient inter-arch space to accommodate the future prothesis.
  • Patients able to comply with the required recall visits.

Exclusion criteria

  • Patients with known systemic diseases, which can affect normal bone formation or blood coagulation.
  • Presence of signs of acute infection or pus formation.
  • Pregnancy.
  • Smoking.
  • Patients on bisphosphonate drug.

Treatment and study plan

Demineralized dentin matrix grafting material

Other

After atraumatic extraction, immediate implant placement will be performed and buccal jumping gap will be filled with demineralized dentin matrix

Demineralized dentin matrix with injectable platelet rich fibrin

Other

After atraumatic extraction, immediate implant placement will be performed and buccal jumping gap will be filled with demineralized dentin matrix mixed with injectable platelet rich fibrin

Primary outcomes

  1. implant stability

    Time frame: 12 months

    implant stability will be measured using Osstell mentor device

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials Around Immediate Dental Implants in the Maxillary Esthetic Zone

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jul 24, 2026
Registry last updated
Jul 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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