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OpenTrials
Completed

NCT Number: NCT03943680

Plasma Rich in Growth Factors in Post-extraction Sockets

The purpose of this study is to compare the clinical success, radiographical volume maintenance and histological bone regeneration after using either a bovine bone xenograft or an autogenous platelet rich plasma enrich in growth factors, known as Endoret®-PRGF®.

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Key information

Conditions

Tooth Extraction Dental Implants

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Facultad de Odontología

Granada, 18071, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Upper or lower premolar or molar tooth in need of extraction and later restoration by dental implant.
  • Adjacent and opposing natural teeth present and healthy.
  • At least 3 mm from the tip of the dental root to the maxillary sinus or the inferior alveolar canal.

Exclusion criteria

  • Active local infection.
  • Uncontrolled diabetes mellitus.
  • Long term (>10 years) use of oral bisphosphonates.
  • Use of intravenous bisphosphonates.
  • Recent use (<3 months) of antibiotics, antiinflammatories or analgesics drugs.
  • Pregnancy.
  • Smokers of more than 10 cigarettes per day.
  • Any oral pathology that needs to be treated before tooth extraction, particularly the presence of more than 25% of sites with bleeding on probing.

Treatment and study plan

PRGF

Device

After tooth extraction, the socket will be grafted with PRGF-Endoret

Other names: PRGF-Endoret

ABB

Device

After tooth extraction, the socket will be grafted with Geistlich Bio-Oss® Collagen

Other names: Geistlich Bio-Oss® Collagen

Primary outcomes

  1. Alveolar bone change in Cone Beam Computerized Tomography

    Time frame: Baseline and 4 months

    Volumetric change in the alveolar bone from immediately after tooth extraction to immediately before implant placement (4 months after the extraction and grafting of the socket)

Sponsors and collaborators

Lead sponsor

Universidad de Granada

Other

Collaborators

  • BTI Biotechnology Institute

Registry information

Official study title

Clinical Behavior and Molecular Pathways of PRGF in Post-extraction Sockets

Important dates

Study start
2019
Primary completion
2024
Study completion
2025
First posted
May 9, 2019
Registry last updated
May 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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