Clinical Study on Emergency Treatment of Cerebral Arteriovenous Malformation Bleeding

Cerebral arteriovenous malformation (AVM) is the leading cause of brain hemorrhage in young adults, characterized by sudden onset and rapid progression. The hybrid neurosurgical operating room is a diagnostic and therapeutic platform that integrates neurointervention and microneurosurgery, offering advantages such as one-stop rapid treatment and multimodal therapeutic approaches.

This study aims to focus on patients with acute cerebral AVM-related hemorrhage through a multicenter, prospective, registry-based research approach. In the hybrid neurosurgical operating room, emergency cerebral angiography, neurointerventional embolization, microsurgical resection of the vascular malformation, or minimally invasive hematoma evacuation will be performed to explore the indications and advantages of the hybrid neurosurgical operating platform in emergency AVM hemorrhage management. The study seeks to establish standardized diagnostic and treatment protocols and operational workflows for emergency AVM hemorrhage management in the hybrid operating room. Through continuous quality improvement, the study aims to further reduce patient morbidity and mortality.

This research will not only enhance the diagnostic and therapeutic level of cerebral AVM-related hemorrhage and improve patient outcomes but also effectively reduce medical costs and societal burdens.

Recruiting

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Key information

Conditions

Arteriovenous Malformation Arteriovenous Malformations Bleeding Brain Diseases Cardiovascular Abnormalities Cardiovascular Diseases Central Nervous System Diseases Central Nervous System Vascular Malformations Cerebral Hemorrhage Cerebrovascular Disorders Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Hemorrhage Intracranial Arterial Diseases Intracranial Arteriovenous Malformations Intracranial Hemorrhages Nervous System Diseases Nervous System Malformations Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases Vascular Malformations

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing Tiantan Hospital, Capital Medical University

Beijing, 100070, China

Location status: Recruiting

Location contact

Yuming Jiao

CONTACT

[email protected]

86-15010108242

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Head CT confirmed cerebral hemorrhage, with indications for emergency surgery
Head CTA suggested that the responsible lesion may be cerebral arteriovenous malformation
Spetzler-Martin classification 1 to 4; Cerebral arteriovenous malformation Spetzler-Martin classification is as follows: ① Nidus size: small (<3 cm) is scored as 1 point, medium (3 cm~6 cm) is scored as 2 points, and large (≥6 cm) is scored as 3 points; ② Adjacent brain functional areas: 0 points for non-functional areas, 1 point for functional areas; ③ Drainage veins: 0 points for superficial veins, 1 point for deep veins);
Aged 18 to 70 years old, with systemic conditions that can tolerate surgery;
Agree to surgical treatment and sign an informed consent form.

Exclusion criteria

Consciousness disorder due to serious underlying diseases
Patients or family members who refuse surgery
Perinatal and pregnancy patients

Treatment and study plan

Primary outcomes

Neurological outcomes

Time frame: 2 weeks, 3 months, 6 months after surgery

modified rankin scale (mRS), The scale runs from 0-6. Higher scores mean a worse outcome

Secondary outcomes

surgical information

Time frame: pre-surgery, during the surgery, perioperatively immediately after the surgery
Complications

Time frame: 2 weeks, 3 months, 6 months after surgery

Study contacts

Contact information is provided by the study sponsor or research team.

Yuming Jiao, MD

CONTACT

[email protected]

86-15010108242

Sponsors and collaborators

Lead sponsor

Beijing Tiantan Hospital

Other

Registry information

Official study title

Clinical Study on Emergency Treatment of Cerebral Arteriovenous Malformation Bleeding and Continuous Improvement of Medical Quality Based on Neurosurgery Hybrid Surgery Platform

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2028
First posted: Aug 12, 2025
Registry last updated: Aug 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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