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NCT Number: NCT06574282

Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study

Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis

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Key information

Conditions

Hypophosphatasia Bone Diseases Bone Diseases, Metabolic Congenital, Hereditary, and Neonatal Diseases and Abnormalities Disease Attributes Genetic Diseases, Inborn Metabolic Diseases Metabolism, Inborn Errors Metal Metabolism, Inborn Errors Musculoskeletal Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Rare Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn

Bonn, North Rhine-Westphali, 53127, Germany

Location status: Recruiting

Location contact

Claus-Jürgen Bauer, MD

CONTACT

[email protected]

+49 228 287-17000

Valentin S. Schäfer, Univ.-Prof. Dr.med. MUDr.

CONTACT

[email protected]

+49 228 287-17000

About this study

Acronym: Expansion:

HPP =Hypophosphatasia COHIR ="Characteristics of Hypophosphatasia in Adult Patients in Rheumatology" ALPL =Alkaline Phosphatase

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Written informed consent
  • Age > 18 years
  • Clinical suspicion of hypophosphatasia
  • Evidence of an abnormal ALP (ALP below LLN) within the clinical routine screening

Exclusion criteria

  • Failure to meet the inclusion criteria listed above

Treatment and study plan

Second alkaline phosphatase measurement

Diagnostic Test

(1-4 weeks after the 1st measurement)

Primary outcomes

  1. Prevalence of hypophosphatasia in adult patients in rheumatology

    Time frame: 36 months

    The primary aim of this prospective observational study is to determine the prevalence of hypophosphatasia in adult patients presenting with musculoskeletal symptoms in rheumatology.

Study contacts

Contact information is provided by the study sponsor or research team.

Claus-Jürgen Bauer, MD

CONTACT

[email protected]

+49 228 287-17000

Valentin S. Schäfer, Univ.-Prof. Dr. med. MUDr.

CONTACT

[email protected]

+49 228 287-17000

Sponsors and collaborators

Lead sponsor

University of Bonn

Other

Registry information

Official study title

The COHIR Multi-center Study - a Non-interventional, Prospective, Multi-center Investigation With Exploratory Data Analysis to Assess the Proportion of Patients With Hypophosphatasia Presenting at the Department of Rheumatology and Establishment of an Algorithm to HPP Diagnosis.

Acronym: COHIRnational

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Aug 27, 2024
Registry last updated
Feb 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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