Cardiac Computed Tomography: Characteristics of Isolated Left Ventricular Non-compaction

The diagnostic criteria for isolated left ventricular non-compaction cardiomyopathy (IVNC) have been well established for echocardiography and cardiac magnetic resonance, such validation is lacking for computed tomography (CT). Such criteria are of great clinical relevance as a growing number of patients undergo a cardiac CT scan in daily clinical routine.

The investigators aim to test the diagnostic accuracy of cardiac CT in distinguishing IVNC from lesser degrees of trabecular layering seen in potential differential diagnoses such as cardiomyopathies and left ventricular hypertrophy or dilation.

The investigators hypothesize that echocardiographic diagnosed pathological trabeculation can be distinguished by determining the ratio of non-compacted to compacted myocardium on cardiac CT.

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Key information

Conditions

Left Ventricular Noncompaction Abnormalities, Multiple Cardiomyopathies Cardiovascular Abnormalities Cardiovascular Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Endocardial Fibroelastosis Genetic Diseases, Inborn Genetic Diseases, X-Linked Heart Defects, Congenital Heart Diseases Isolated Noncompaction of the Ventricular Myocardium

Age range

30 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Zurich, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Established diagnosis of IVNC or differential diagnosis
Age: Men > 30 years, women > 50 years without menstruation for at least 2 month.
Written informed consent to participate

Exclusion criteria

Contraindication for cardiac CT

Renal insufficiency (GFR < 60ml/min)
Known allergy to iodinated contrast agent
Known Hyperthyroidism
Non-sinus rhythm
Known premature ventricular or supraventricular beats
Hypotension (systolic blood pressure < 100mmHg)

Contraindication for CMR

Implanted cardiac pacemaker or defibrillator
Other implanted medical devices (e.g. implantable cardioverter-defibrillator)
Claustrophobia
Known premature ventricular or supraventricular beats
Pregnancy
Claustrophobia

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Important dates

Study start: 2011
Primary completion: 2014
Study completion: 2014
First posted: Nov 10, 2011
Registry last updated: Dec 10, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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