Can Total Mechanical Power Be a Determinant of Weaning Failure in Chronic Obstructive Pulmonary Disease (COPD)?

A Comparison of Ventilator Parameters (TV, DP, Total Mechanical Power, etc.) Between Successfully and unsuccessfully Weaned Patients with COPD Undergoing Mechanical Ventilation Due to Respiratory Failure, and Diagnosed with Pneumonia or ARDS in the Intensive Care Unit."

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Key information

Conditions

COPD (Chronic Obstructive Pulmonary Disease) ARDS (Acute Respiratory Distress Syndrome) Acute Lung Injury Chronic Disease Disease Attributes Infections Lung Diseases Lung Diseases, Obstructive Lung Injury Mechanical Power Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases Respiratory Tract Infections Weaning Failure

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Bakirkoy Dr Sadi Konuk Research and Training Hospital

Istanbul, Turkey (Türkiye)

About this study

The objective of this study is to investigate which mechanical ventilation parameters and clinical findings influence weaning success by comparing successful and unsuccessful weaning patient groups among patients diagnosed with COPD who were intubated and monitored for more than five days in the intensive care unit. The findings of this study may contribute to the development of future treatment protocols and criteria for evaluating the weaning process.

This study is planned to be conducted in two centers: Bakırköy Dr. Sadi Konuk Training and Research Hospital in Istanbul and Shahid Beheshti University of Medical Sciences, Masih Daneshvari Hospital in Tehran. This multicenter study aims to facilitate the comparison of data obtained under different geographical and clinical conditions, thereby enabling a broader analysis of factors influencing the weaning process across a larger patient population.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 18 years and older
COPD-diagnosed patients who have been intubated and stayed in the ICU for more than 5 days

Exclusion criteria

Patients without electronic medical records
Patients under 18 years of age
Patients diagnosed with pulmonary malignancy
Patients who stayed in the ICU for less than 5 days
Patients monitored in the ICU without intubation

Treatment and study plan

Primary outcomes

Successful Weaning

Time frame: 48 hours

The primary outcome of this study will be the successful weaning from mechanical ventilation. This will be defined as the patient being successfully extubated and maintaining adequate oxygenation for more than 48 hours without requiring reintubation or mechanical ventilation support.

Secondary outcomes

Mechanical Ventilator Parameters

Time frame: 48 hours

A comparison of total mechanical power between the weaned and non-weaned patient groups.

Sponsors and collaborators

Lead sponsor

Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Other Gov

Collaborators

Masih Daneshvari Hospital

Registry information

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Dec 30, 2024
Registry last updated: Dec 30, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed