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NCT Number: NCT02859194

The Effect of Lt to Rt Shunt Using Veno-veno-arterial Extracorporeal Membrane Oxygenation (ECMO) on Coronary Oxygenation in Lung Transplantation Patients

ECMO(Extracorporeal membrane oxygenation) is being essential for cardiopulmonary failure patients. There are two types of ECMO, which is veno-veno (V-V) that can be used in respiratory failure patients and veno-arterial (V-A) that can be used in cardiac failure patients. V-A ECMO can also be used during lung transplantation, substitution of cardiopulmonary bypass, which can show sufficient performance during operation and better postoperative outcome. However, regarding V-A ECMO circulating from femoral vein to femoral artery, there is a pro blem of differential hypoxia which might influence coronary artery and head vessels. In this prospective study, the investigators are planning to put another ECMO catheter into internal jugular vein which takes a role of left to right shunt, to mitigate the hypoxia of coronary artery.

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Key information

Conditions

Interstitial Pulmonary Fibrosis ARDS ARDS (Acute Respiratory Distress Syndrome) Acute Lung Injury Bronchial Diseases Bronchiectasis COPD (Chronic Obstructive Pulmonary Disease) Chronic Disease Disease Attributes Familial Primary Pulmonary Hypertension Hemic and Lymphatic Diseases Hypertension, Pulmonary Immune System Diseases Immunoproliferative Disorders Lung Diseases Lung Diseases, Obstructive Lung Injury Lymphangioleiomyomatosis Lymphangiomyoma Lymphatic Diseases Lymphoproliferative Disorders Neoplasm, Lymphatic Tissue Neoplasms Neoplasms by Histologic Type Neoplasms, Connective and Soft Tissue Pathologic Processes Pathological Conditions, Signs and Symptoms Perivascular Epithelioid Cell Neoplasms Primary Pulmonary Hypertension Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine

Seoul, 120-752, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • scheduled for double lung transplantation

Exclusion criteria

  • patients who have history of coronary artery occlusive disease
  • patients with arrhythmia

Treatment and study plan

Veno-veno-arterial ECMO

Procedure

Primary outcomes

  1. arterial blood oxygen partial pressure (PaO2)

    Time frame: 5 min after jugular catheter flow 0ml/min

  2. arterial blood oxygen partial pressure (PaO2)

    Time frame: 5 min after jugular catheter flow 500 ml/min

  3. arterial blood oxygen partial pressure (PaO2)

    Time frame: 5 min after jugular catheter flow 1,000ml/min

  4. arterial blood oxygen partial pressure (PaO2)

    Time frame: 5 min after jugular catheter flow 1,500ml/min

Secondary outcomes

  1. venous blood oxygen partial pressure (PvO2)

    Time frame: 5 min after jugular catheter flow 0ml/min

  2. venous blood oxygen partial pressure (PvO2)

    Time frame: 5 min after jugular catheter flow 500 ml/min

  3. venous blood oxygen partial pressure (PvO2)

    Time frame: 5 min after jugular catheter flow 1,000ml/min

  4. venous blood oxygen partial pressure (PvO2)

    Time frame: 5 min after jugular catheter flow 1,500ml/min

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Aug 8, 2016
Registry last updated
Jul 18, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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