Bariatric Surgery and Sperm Quality

In order to assess how bariatric surgery may influence their fertility parameters, patients will attend to 3 visits :

First visit (inclusion, before surgery) :

• Signature of consent
• Patient interview (Collection of data on background, treatments, socio-demographic characteristics, social and familial environment, food consumption and habits, tobacco and alcohol use, physical activity, libido and quality of life (surveys))
• Clinical examination and anthropometric assessment (BMI, blood pressure, expired CO)
• Blood samples (Metabolic and nutritional plasmatic biomarkers ; Plasmatic oxidative stress biomarkers ; antioxidants micronutrients ; hormones of adiposity and inflammation ; sex hormones ; persistent contaminants)
• Sperm sample (sperm count-morphology ; DNA fragmentation ; CASA)

Bariatric surgery

Second visit (6 month follow-up)

• Report of adverse events if any
• Surveys
• Blood and sperm samples

Third visit (12 month follow-up)

• Report of adverse events if any
• Blood and sperm samples

Inclusion criteria

• Obese men with BMI ≥ 40kg/m² or 35 kg/m² with associated co-morbidities
• Selected for bariatric surgery by multidisciplinary team
• From 18 to 50 years old included
• With a first medical consultation and its results
• With their written informed consent to participate in the study
• No problem for understanding verbal or written French
• An affiliation to social security

Exclusion criteria

• Not candidates for surgery
• With non idiopathic alteration of spermatogenesis