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NCT Number: NCT07451938

A Cohort Study on Obese Patients' Multidisciplinary Integrated Health Management

To explore influencing factors of diabetes remission and recovery of other complications after bariatric surgery. We design a multicenter study including respective cohort and prorespective cohort of obese patients treated with bariatric surgery or non-bariatric surgery，and collect clinical parameters and laboratory indicators.

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Key information

Conditions

Obesity Bariatric Surgery Body Weight Diabete Type 2 Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

12 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

China-Japan Friendship Hospital

Beijing, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age range from 12 to 75 years,
  • BMI (Body Mass Index) ≥ 25.0 kg/m2,

Exclusion criteria

  • Type 1 diabetes,
  • Severe liver or kidney disease (eGFR < 30 ml/min), malignant tumors, endocrine disorders such as thyroid or Cushing's syndrome, acute coronary syndrome, uncontrolled heart failure, pregnancy or lactation, pancreatitis,
  • Contraindications to other surgeries or medications.

Treatment and study plan

bariatric surgery

Procedure

Laparoscopic sleeve gastrectomy or laparoscopic gastric bypass based on β-cell function

Non-surgical threapy

Other

Diet management，exercise，metformin，GLP-1RA and other drugs which can lose weight.

Primary outcomes

  1. Total weight loss

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

Secondary outcomes

  1. Fasting blood glucose

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  2. Average blood glucose from continuous glucose monitoring

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  3. Postprandial 2-hour blood glucose

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  4. HbA1c

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  5. Waist circumference and hip circumference

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  6. Medication status

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  7. Quality of life score

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  8. AHI

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  9. GERDQ Score

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  10. Urinary microalbumin

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  11. Serum creatinine

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  12. TC

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

  13. TG

    Time frame: 1st, 3rd, 6th and 12th month after intervention, respectively.

Sponsors and collaborators

Lead sponsor

China-Japan Friendship Hospital

Other

Registry information

Acronym: ODHM

Important dates

Study start
2017
Primary completion
2025
Study completion
2025
First posted
Mar 5, 2026
Registry last updated
Mar 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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