Assessment of Voriconazole Penetration Into the Brain by Fluorine-Magnetic Resonance Spectroscopy

The purpose of this study is to determine the amount of voriconazole in the brain by fluorine-magnetic resonance spectroscopy (MRS) and to compare brain levels to plasma levels.

Completed

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Key information

Conditions

Fungal Infection Bacterial Infections and Mycoses Infections Mycoses

Age range

18 year–55 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 1

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy male volunteers 18-55 years of age

Exclusion criteria

Subjects with any condition affecting drug absorption
Subjects with a positive urine drug screen

Treatment and study plan

Voriconazole

Drug

Primary outcomes

Assess brain levels of voriconazole in the brain using a non-evasive technique of MRS

Sponsors and collaborators

Lead sponsor

Pfizer

Industry

Collaborators

Mclean Hospital

Registry information

Important dates

Study start: 2005
Study completion: 2005
First posted: Aug 29, 2005
Registry last updated: Mar 12, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed