NCT Number: NCT05904301
Longitudinal prospective multicenter Armenian registry of systemic autoimmune, autoinflammatory diseases with constitution of bio-banking.
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Observational
Erebouni Medical Center, Rheumatology Department, Yerevan, Armenia
Autoimmune and auto inflammatory diseases are a growing group of disorders caused by a dysregulation of the innate immune system leading to episodes of systemic inflammation.
They represent a group of diseases characterized by excessive autoimmune or inflammatory reaction leading to various organ damage and drop in patient's quality of life, usually underlined by particular genetic factors and environmental triggers.
The progress of these diseases is often evaluated in the form of activity scores.
A number of scores are available to predict the evolution of autoimmune autoinflammatory diseases.
For a long time, these pathologies have remained slightly explored because of their complex physiopathology and the absence of specific therapies.
In the last few years, significant progress has been made in terms of both pathophysiology and treatment.
Treatment with biological targeted therapies transformed the prognosis and survival of the patients, improved their quality of life and underlined the necessity of a global management of these patients.
In Armenia, the epidemiological elements of these pathologies are not known, nor are the circumstances of their discovery. The initial biological manifestations and the management of these patients are variable from one center to another, whether in terms of supportive or specific therapeutic elements.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Behcet disease, ANCA -positive vasculitis, Takayasu arteritis, Giant cell arteritis, Systemic sclerosis, Sjogren syndrome, Rheumatoid arthritis, Spondylarthritis (psoriatic, ankylosing, crohn's related), Angioedema hereditary and acquired, Pediatric dermatology, Autoinflammatory diseases (hereditary and acquired), Unexplained infertility, Immune thrombocytopenic purpura/ Autoimmune hemolytic anemia (ITP, AHA), Primary anti-phospholipid syndrome (APS), Celiac disease.
Exclusion criteria
For all systemic diseases the following data will be collected:
Clinical examination, Laboratory data, Current medications, Constitution of biobanking.
For each disease:
Pathology specific Activity score, Global subjective disease activity by patient and by physician.
Time frame: Through study completion, an average of 5 years
Description of Initial manifestations and the progress of these diseases.
The progress of these diseases is assessed in the form of disease-specific activity scores:
Time frame: Through study completion, an average of 5 years
Clinical and biological correlations to characterize rare clinical forms of each pathology
Time frame: Through study completion, an average of 5 years
Interest in prognostic factors obtained through more targeted radiological examinations and correlation with the response to different treatments.
Contact information is provided by the study sponsor or research team.
Santé Arménie French-Armenian Research Center
Other
Acronym: NAREG
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