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Completed

NCT Number: NCT04828642

Antioxidant Vitaminas and Hypertrophy Adaptations to Resistance Training

This investigations aims to investigate whether supplementation with antioxidant vitamins (vitamin C and vitamin E) can influence, enhancing or blocking, the hypertrophic adaptations caused by strength training in sedentary subjects.

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Key information

Conditions

Hypertrophy Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Universidad Europea de Madrid

Madrid, 28011, Spain

About this study

A randomized, double-blind, placebo-control controlled trial will be conducted. In a previous session volunteers will be interviewed to determine if they meet the inclusion criteria. Will be done two weeks of flushing out other types of supplementation and strenuous physical exercise, along with familiarization with the strength training program and performance tests to be carried out during the rehearsal. Subsequently, it will be a week without exercising to start with the experimental designs. From the start of the trial, participants should avoid physical exercise. strenuous outside the training protocol and if usual, they will only be able to perform one resistance training session per week. Participants should avoid ingesting of foods that contain high amounts of antioxidant compounds: more than two juices of fruits, more than four cups of coffee or tea. Juices with high antioxidant content should be avoided. Alcoholic beverages should also be avoided.

  • Group 1 (G1): Antioxidant vitamins (VitC (1000 mg) + VitE (235 mg)) + exercise
  • Group 2 (G2): Placebo + exercise A supplementation period of 12 weeks will be carried out. In each period, supplementation with antioxidant vitamins: VitC (1000 mg) + VitE (235 mg) or with placebo.

All participants will ingest the supplementation between 1-3 hours before training, the days of rest in the mornings.

All participants will perform a 12-week strength training protocol. The training session performed in the sharp design will be the first training session in chronic design. Being the baseline (E0) and post-exercise (E1) assessment performed in G1, G2 and G3 also the first evaluation corresponding to the chronic design.

In the middle of the supplementation period (week 6) and at the end, two new evaluations (week 12). Baseline evaluations will be performed prior to an exercise session of week 6 (E2) and at the last exercise session (E3) of the following parameters: performance physique, body composition, micronutrient analysis, muscle ultrasound. I also know conduct post-exercise physical performance assessments Figure 2.

The strength training protocol will be carried out 4 days a week at the facilities sports of the European University. The sessions will be planned by a professional from the Sciences of Physical Activity and Sports. Sessions will be tracked through a diary.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Experience in strength training of at least one year

Exclusion criteria

  • Smokers
  • Antioxidant supplementation
  • Injuries or diseases

Treatment and study plan

Vitamin C and vitamin E

Dietary Supplement

1000 mg 235 mg

Other names: Ascorbic acid and tocopherol

Placebo

Dietary Supplement

Placebo

Primary outcomes

  1. DEXA

    Time frame: Week 0

    Evaluation of muscle mass with dual energy X-ray absorptiometry

  2. DEXA

    Time frame: Week 10

    Evaluation of muscle mass with dual energy X-ray absorptiometry

  3. Anthropometry

    Time frame: Week 0

    Evaluation of muscle mass by a ISAK 1 level anthropometrist

  4. Anthropometry

    Time frame: Week 5

    Evaluation of muscle mass by a ISAK 1 level anthropometrist

  5. Anthropometry

    Time frame: Week 10

    Evaluation of muscle mass by a ISAK 1 level anthropometrist

  6. Bioimpedance

    Time frame: Week 0

    Evaluation of muscle mass with an Inbody

  7. Bioimpedance

    Time frame: Week 5

    Evaluation of muscle mass with an Inbody

  8. Bioimpedance

    Time frame: Week10

    Evaluation of muscle mass with an Inbody

  9. DOMS

    Time frame: Week 0

    Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain)

  10. DOMS

    Time frame: Week 5

    Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain)

  11. DOMS

    Time frame: Week 10

    Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain)

  12. Manual dinamometry

    Time frame: Week 0

    Handgrip

  13. Manual dinamometry

    Time frame: Week 5

    Handgrip

  14. Leg dinamometry

    Time frame: Week 0

    Dinamometer

  15. Leg dinamometry

    Time frame: Week 5

    Dinamometer

  16. Leg dinamometry

    Time frame: Week 10

    Dinamometer

  17. RPE

    Time frame: Week 0

    10-point scale (no exertion 0- maximal effort 10)

  18. RPE

    Time frame: Week 5

    10-point scale (no exertion 0- maximal effort 10)

  19. RPE

    Time frame: Week 10

    10-point scale (no exertion 0- maximal effort 10)

  20. 1 RM

    Time frame: Week 0

    Bench press and squats

  21. 1 RM

    Time frame: Week 5

    Bench press and squats

  22. 1 RM

    Time frame: Week 10

    Bench press and squats

  23. Parameters determined by ENCODER

    Time frame: Week 0

    Bench press and squats

  24. Parameters determined by ENCODER

    Time frame: Week 5

    Bench press and squats

  25. Parameters determined by ENCODER

    Time frame: Week 10

    Bench press and squats

Sponsors and collaborators

Lead sponsor

Universidad Europea de Madrid

Other

Registry information

Official study title

Vitamins C and Vitamin E and Hypertrophy Adaptations to Resistance Traini

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Apr 2, 2021
Registry last updated
Aug 3, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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