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Completed

NCT Number: NCT05774444

Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism

The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.

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Key information

Conditions

Hypertrophy Behavior Motor Activity Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms

Age range

60 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Stuart Robert Gray

Glasgow, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Be 60 years old or older
  • Have a BMI of less than 35kg/m2
  • Be participating in structured exercise for less than 2h per week

Exclusion criteria

  • Diabetes
  • Severe cardiovascular disease
  • Seizure disorders,
  • Uncontrolled hypertension (>150/90mmHg at baseline measurement)
  • Cancer or cancer that has been in remission <5 years
  • Ambulatory impairments which would limit ability to perform assessments of muscle function
  • Dementia
  • Taking medication known to affect muscle (e.g., steroids)
  • Have an implanted electronic device (e.g., pacemaker/defibrillator/insulin pump),
  • Anticoagulant therapy
  • Allergies to seafood
  • Regular consumption of more than 1 portion of oily fish per week.

Treatment and study plan

Krill oil

Dietary Supplement

Krill oil will be supplemented to see if they can gain strength and/or muscle mass following supplementation.

Krill protein

Dietary Supplement

Krill protein will be given to the participant following a resistance exercise bout.

Vegetable oil

Dietary Supplement

This will be the control against the Krill oil

Carbohydrate

Dietary Supplement

This will be the control for the Krill protein

Primary outcomes

  1. Post-exercise muscle protein synthesis

    Time frame: 3-7 hours

    Muscle protein synthesis measured 3-7h after a single bout of resistance exercise

Secondary outcomes

  1. Change in Muscle thickness

    Time frame: Change from baseline to 8 weeks

    Vastus lateralis muscle thickness measured by ultrasound

  2. Change in grip strength

    Time frame: Change from baseline to 8 weeks

    Grip strength measured with a Jamar dynamometer

  3. Change in fat mass

    Time frame: Change from baseline to 8 weeks

    Whole body fat mass measured by BIA

  4. Change in lean mass

    Time frame: Change from baseline to 8 weeks

    Whole body lean mass measured by BIA

  5. Change in muscle strength

    Time frame: Change from baseline to 8 weeks

    Knee extensor muscle strength measured isometrically

  6. Change in Chair rise time

    Time frame: Change from baseline to 8 weeks

    Time taken to get up and down from a chair 5 times

  7. Change in balance

    Time frame: Change from baseline to 8 weeks

    Ability to stand for 10 seconds in full tandem, semi-tandem and feet together

  8. Change in gait speed

    Time frame: Change from baseline to 8 weeks

    Time taken to walk 4 metres at a normal walking pace

  9. Basal muscle protein synthesis

    Time frame: 0-3 hours

    Muscle protein synthesis measured from 0-3h after an overnight fast

  10. Change in Erythrocyte fatty acid profile

    Time frame: Change from baseline to 8 weeks

    Erythrocyte fatty acid profile

Sponsors and collaborators

Lead sponsor

University of Glasgow

Other

Collaborators

  • Aker BioMarine

Registry information

Official study title

Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism: a Randomised Controlled Trial

Acronym: KIPLING

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Mar 17, 2023
Registry last updated
Apr 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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