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Active, Not Recruiting

NCT Number: NCT02984163

Alberta Cancer Exercise Hybrid Effectiveness-Implementation Study

The primary purpose of this proposed 5-year hybrid effectiveness and implementation study is to evaluate the relative benefit from, and implementation of an Alberta wide clinic-to-community-based cancer and exercise model of care - the Alberta Cancer Exercise (ACE) Program. The investigators hypothesize that the strategy will improve the physical well-being and QoL of survivors (on and off cancer treatment) while preventing the development of secondary cancers.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Calgary/ Tom Baker Cancer Centre, Calgary, Alberta, Canada

Loading trial locations.

About this study

A total of 2500 adult cancer survivors will be enrolled in the 5-year study. The investigators will build capacity by expanding ACE training and programming to sites beyond the large urban centers. The investigators plan for implementation in 7 Alberta YMCAs and/or City Recreation facilities within 3 years, as well as to formally establish partnerships within AHS to build further capacity across the province within existing AHS programming (e.g., CancerControl Rehab Services, Alberta Healthy Living Program and Primary Care Network). Virtual and supported home-based options will be available as an alternative.

Eligible and consenting participants will be screened for exercise safety, and following fitness testing will be triaged to appropriate exercise programming in their home or community. The exercise intervention will take place at the survivor's home, YMCAs and municipal fitness centres across the province. The supported home-based and community-based exercise program will be administered by exercise specialists who have undergone the ACE Cancer and Exercise: Training for Fitness Professionals course. Survivors will take part in a combination of aerobic, resistance, balance, and flexibility exercises delivered in a circuit-type class setting or group personal training format, twice weekly for an 8-to-12-week period.

Effectiveness outcomes include physical fitness, physical activity, quality of life, and healthcare utilization. These outcomes are known factors associated with the secondary prevention of cancer. The RE-AIM framework will be used to evaluate program reach, effectiveness, adoption, implementation and maintenance. The Alberta Quality Matrix for Health will serve as a framework to inform program sustainability beyond the funding period. Through this research, the investigators will better understand the effectiveness of the ACE program, and evaluate processes to support future implementation and sustainability.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • have a diagnosis of cancer;
  • be over the age of 18 years;
  • be able to participate in low-intensity levels of activity at minimum;
  • be pretreatment, or receiving active cancer treatment (i.e., surgery, systemic therapy and radiation therapy), or have received cancer treatment within the past 3 years; or have ongoing significant cancer or treatment-related impairments (requiring supportive exercise intervention);
  • be able to provide informed written consent in English.

Exclusion criteria

  • Inability or deemed unsafe to participate in physical activity program

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Treatment and study plan

Exercise

Behavioral

Exercise sessions will include a combination of aerobic, resistance, balance, and flexibility exercises delivered in a circuit-type class setting or group personal training format.

Other names: Physical Activity

Primary outcomes

  1. Physical Activity Minutes Per Week

    Time frame: Baseline to One-year

    Change in number of participants meeting Guidelines for Physical Activity of 150 minutes per week of moderate intensity exercise

Secondary outcomes

  1. Aerobic Endurance

    Time frame: Baseline to One-year

    Change in 6 minute walk test distance (metres)

  2. Quality of Life Cancer Specific

    Time frame: Baseline to One year

    Change in Functional Assessment of Cancer Therapy General Scale

  3. General Health-related Quality of Life

    Time frame: Baseline to One-year

    Change in Rand Short Form (SF)-36

  4. Fatigue

    Time frame: Baseline to One-year

    FACT-Fatigue subscale

  5. Upper extremity grip strength

    Time frame: Baseline to One-year

    Change in hand-grip dynamometry (kg)

  6. Functional performance test

    Time frame: Baseline to One-year

    Change in sit-to-stand (number in 30 seconds)

  7. Upper extremity flexibility

    Time frame: Baseline to One-year

    Change in active shoulder flexion range of motion (degrees)

  8. Lower extremity flexibility

    Time frame: Baseline to One-year

    Change in sit-and-reach test (cm)

  9. Balance

    Time frame: Baseline to One-year

    Change in one legged stance test (seconds)

  10. Cost-effectiveness evaluation

    Time frame: Baseline to One-year

    EQ-5D questionnaire

  11. Exercise adherence

    Time frame: Baseline to 12-weeks

    Adherence to exercise programming (attendance at sessions)

  12. Body Composition

    Time frame: Baseline to One-year

    Change in BMI

  13. Waist and hip measurements

    Time frame: Baseline to One-year

    Change in waist and hip circumference (cm) and change in waist-to-hip ratio

  14. Program implementation and evaluation

    Time frame: Baseline to One-year

    RE-AIM: program reach, effectiveness, adoption, implementation and maintenance

  15. Adverse events

    Time frame: Baseline to One-year

    Adverse event rates

Other outcomes

  1. Home-based programming stepping test

    Time frame: Baseline to One-year

    2-minute stepping test

  2. 1RM or 8RM strength (optional)

    Time frame: Baseline to One-year

    Change in bench press, vertical row and leg press strength (kg)

  3. Muscular endurance test (optional)

    Time frame: Baseline to One-year

    Change in number of push-ups

  4. Core endurance test (optional)

    Time frame: Baseline to One-year

    Change in plank test (seconds held)

Sponsors and collaborators

Lead sponsor

University of Alberta

Other

Collaborators

  • Alberta Health services
  • Cross Cancer Institute
  • Tom Baker Cancer Centre
  • University of Calgary

Registry information

Official study title

The Alberta Cancer Exercise "ACE" Program for Cancer Survivors: Supporting Community-based Exercise Participation for Health Promotion and Secondary Cancer Prevention

Acronym: ACE

Important dates

Study start
2017
Primary completion
2024
Study completion
2026
First posted
Dec 6, 2016
Registry last updated
Aug 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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