Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT03424668

The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Neoplasms Behavior Cardiovascular Diseases Death Motor Activity Pathologic Processes Pathological Conditions, Signs and Symptoms Smoking

Age range

39 year–79 year

Sex eligibility

All sexes

Study type

Observational

About this study

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease. Detailed data on sociodemographic, lifestyle, medical and family history were collected and a biological sample bank including urine and blood samples established. Participants have been followed up through repeat examinations, mailed questionnaires as well as through record linkage with routine health records including death certification by cause, cancer registration and hospital admissions by cause till present.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Willing to participate
  • On general practice age sex registers in Norfolk, United Kingdom in 1993-1997

Exclusion criteria

  • Not willing to participate in study
  • terminal illness

Treatment and study plan

Diet

Behavioral

lifestyle factors

Other names: physical activity

Primary outcomes

  1. neoplasms

    Time frame: Through 25 years

    cancer incidence

Secondary outcomes

  1. cardiovascular diseases

    Time frame: through 25 years

    incidence of cardiovascular diseases

  2. death

    Time frame: through 25 years

    total mortality by cause

Other outcomes

  1. fractures

    Time frame: through 25 years

    incident fractures

  2. diabetes mellitus

    Time frame: through 25 years

    incident diabetes

Sponsors and collaborators

Lead sponsor

University of Cambridge

Other

Collaborators

  • Cancer Research UK
  • Medical Research Council

Registry information

Acronym: EPIC-Norfolk

Important dates

Study start
1992
Primary completion
2040
Study completion
2040
First posted
Feb 7, 2018
Registry last updated
Apr 16, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.