ACC - Atrial Contribution to CRT

All patients will undergo advanced echocardiographic examination pre-operative, pre-discharge after implantation and at 3 and 6-months follow-up. AV-delay optimization will be performed using aortic VTI measured by continuous wave Doppler in a modified 4-chamber view. During optimisation aortic VTI will be measured at different heart rates reached by increasing atrial pacing 10, 20 and 30 beats above intrinsic heart rate (IHR).

Inclusion criteria

• Symptoms of heart failure
• Left ventricular dysfunction
• Ventricular dyssynchrony
• 18 years or of legal age in order to give informed consent according to national laws
• Able to understand the nature of the procedure
• Available for follow-up on a regular basis at an approved investigational center

Exclusion criteria

• Atrial Fibrillation
• Life expectancy of less than six months due to other medical conditions
• For women: pregnancy or absence of medically accepted birth control
• Inability or refusal to sign the Patient Informed Consent
• Inability or refusal to comply with the follow up schedule or protocol requirements
• Inability to undergo device implant, including general anaesthesia if required
• Mechanical tricuspid prosthesis
• Currently enrolled in another investigational study, including drug investigations
• Hypertrophic Obstructive Cardiomyopathy (HOCM)
• Not meeting the inclusion criteria