CHU Brabois
Vandœuvre-lès-Nancy, 54511, France
Completed
NCT Number: NCT06878768
Translational Research GRICS-CineCardiac
This project is a pilot study which aims at showing the feasibility of free breathing cardiac MRI using GRICS (Generalized Reconstruction by Inversion of Coupled System)software in a clinical environment.
The GRICS technique has been developed by the IADI (Diagnostic, Adaptive and Interventional Imaging)lab, Nancy, France. It enables free breathing MRI thanks to a reconstruction algorithm which provides artefact-free images based on raw MR data and physiological data from external sensors (respiratory belts, ECG.
In this study, we want to acquire free breathing cardiac cine images during a standard cardiac MR exam and compare those data with the breath-hold ones.
Completed
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Notify MeKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- candidate to cardiac MR exam because of ischemic or dilated cardiopathy
- legally an adult
- having heath insurance
- having signed the consent form
Exclusion criteria
- dyspnea
- atrial fibrillation
- pain while lying on the back for a long time
- inability to follow a procedure
- contraindication to MRI
- contraindication to gadolinium chelate injection
Treatment and study plan
Additional free breathing MR acquisitions
DevicePrimary outcomes
-
Qualitative image reading by the radiologist
Time frame: 1 Month
Feasibility of GRICS CardioCine : the radiologist responds to a questionnaire
-
Quantitative image analysis by the radiologist
Time frame: 1 Month
Feasibility of GRICS CardioCine : the radiologist responds to a questionnaire
Secondary outcomes
-
Right ventricular end-diastolic volume
Time frame: Day 1
Free-breathing and breath-hold measurements
-
Left ventricular end-diastolic volume
Time frame: Day 1
Free-breathing and breath-hold measurements
-
Right ventricular end-systolic volume
Time frame: Day 1
Free-breathing and breath-hold measurements
-
Left ventricular end-systolic volume
Time frame: Day 1
Free-breathing and breath-hold measurements
-
Right ventricular systolic ejection volume
Time frame: Day 1
Free-breathing and breath-hold measurements
-
Left ventricular systolic ejection volume
Time frame: Day 1
Free-breathing and breath-hold measurements
-
Right ventricular ejection fractions
Time frame: Day 1
Free-breathing and breath-hold measurements
-
Left ventricular ejection fractions
Time frame: Day 1
Free-breathing and breath-hold measurements
-
Left ventricular mass in diastole
Time frame: Day 1
Free-breathing and breath-hold measurements
-
Aortic flow
Time frame: Day 1
Free-breathing and breath-hold measurements
-
Analysis of the segmental kinetics of the left ventricle
Time frame: Day 1
Free-breathing and breath-hold measurements
Sponsors and collaborators
Lead sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Other Gov
Registry information
Official study title
Imagerie Cardiaque Ciné Par résonance magnétique en Respiration Libre
Important dates
- Study start
- 2011
- Primary completion
- 2012
- Study completion
- 2012
- First posted
- Mar 17, 2025
- Registry last updated
- Apr 23, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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