A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic Development

Thalassemia is an anemia or pathological state caused by compounding absently or inadequately of one or more globin chains of hemoglobin due to the defects of the globin gene,and the carrying rate is high in southern China. Although there are many studies of Thalassemia, the relationship between the globin gene defects and the early embryo development has not been reported.

This study intends to carry out a retrospective analysis on the embryonic development of the patients with thalassemia assisted by PGD from January 1, 2011 to now in our hospital, to explore whether the HBA or HBB gene defects have a certain influence on the early embryo development, so as to accumulate certain data for reproductive health research.

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Key information

Conditions

Thalassemia,Embryonic Development,Reproductive Sterility and Infertility Anemia Anemia, Hemolytic Anemia, Hemolytic, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Genital Diseases Hematologic Diseases Hemic and Lymphatic Diseases Hemoglobinopathies Infertility Thalassemia Urogenital Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Reproductive & Genetic Hospital of CITIC-XIANGYA

Changsha, Hunan, 410008, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

infertility couples with thalassemia(one or both )
infertility couples treat by PGD

Exclusion criteria

abortion of amplification for blastula biopsy
PGD without diagnostic results or with unclear diagnostic results
embryos with both HBA and HBB genetic defect

Treatment and study plan

Preimplantation Genetic Diagnosis

Procedure

Primary outcomes

Gardner grading of blastocysts

Time frame: embryo cultured in-vitro for 5-7 days

development status of blastocysts

Sponsors and collaborators

Lead sponsor

Reproductive & Genetic Hospital of CITIC-Xiangya

Other

Registry information

Important dates

Study start: 2013
Primary completion: 2018
Study completion: 2020
First posted: Sep 27, 2018
Registry last updated: Jan 11, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed