Skip to main content
OpenTrials

Clinical trial condition

Optic Atrophy, Hereditary, Leber

Explore clinical trials studying Optic Atrophy, Hereditary, Leber. Study availability and eligibility vary by location and protocol.

33 public trials 7 recruiting studies
Refine in advanced search Browse all conditions

Optic Atrophy, Hereditary, Leber trial results

Active, not recruiting

Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND4 Mutations

NCT05293626

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Cranial Nerve Diseases, Eye Diseases, +13 more
Locations
  • Stanford Byers Eye Institute Palo Alto, California, United States
  • University of Colorado Health Eye Center Aurora, Colorado, United States
  • Wills Eye Hospital, Neuro Ophthalmology Department Philadelphia, Pennsylvania, United States
View Trial Details
Active, not recruiting

A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)

NCT03913143

Conditions
Blindness, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, +26 more
Locations
  • University of Iowa Iowa City, Iowa, United States
  • Universitair Ziekenhuis Gent (UZ) Ghent, Belgium
  • INRET Clínica/ Santa Casa de Misericórdia de Belo Horizonte Belo Horizonte, Minas Gerais, Brazil
  • Federal University of São Paulo - Hospital São Paulo (UNIFESP-HSP) São Paulo, Brazil
View all 14 locations
View Trial Details
Completed

Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year

NCT03293524

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Cranial Nerve Diseases, Eye Diseases, +13 more
Locations
  • Doheny Eye Center UCLA Pasadena Pasadena, California, United States
  • University of Colorado Health Eye Center Aurora, Colorado, United States
  • Emory Healthcare - The Emory Clinic Atlanta, Georgia, United States
  • Massachusetts Eye and Ear Infirmary Boston, Massachusetts, United States
View all 13 locations
View Trial Details
Completed

REALITY LHON Registry

NCT03295071

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Cranial Nerve Diseases, Eye Diseases, +13 more
Locations
  • Doheny Eye Center UCLA Pasadena Pasadena, California, United States
  • Emory University Hospital Atlanta, Georgia, United States
  • Massachusetts Eye and Ear Infirmary Boston, Massachusetts, United States
  • Wills Eye Institute Philadelphia, Pennsylvania, United States
View Trial Details
Completed

RESCUE and REVERSE Long-term Follow-up

NCT03406104

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Cranial Nerve Diseases, Eye Diseases, +13 more
Locations
  • Doheny Eye Center UCLA Pasadena, California, United States
  • Emory University Hospital Atlanta, Georgia, United States
  • Wills Eye Institute Philadelphia, Pennsylvania, United States
  • CHNO Les Quinze Vingts Paris, France
View Trial Details
Completed

Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE)

NCT02652780

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Cranial Nerve Diseases, Eye Diseases, +13 more
Locations
  • Doheny Eye Center, University of California, Los Angeles Los Angeles, California, United States
  • Department of Ophthalmology, Emory University School of Medicine Atlanta, Georgia, United States
  • Neuro Ophthalmologic Associates, Wills Eye Hospital, Thomas Jefferson University Philadelphia, Pennsylvania, United States
  • Centre National Hospitalier d'Ophtalmologie des Quinze-Vingt Paris, France
View Trial Details
Completed

Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation

NCT02652767

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Cranial Nerve Diseases, Eye Diseases, +13 more
Locations
  • Doheny Eye Center, University of California, Los Angeles Los Angeles, California, United States
  • Department of Ophthalmology, Emory University School of Medicine Atlanta, Georgia, United States
  • Neuro Ophthalmologic Associates, Wills Eye Hospital, Thomas Jefferson University Philadelphia, Pennsylvania, United States
  • Centre National Hospitalier d'Ophtalmologie des Quinze-VingtCentre National Hospitalier d'Ophtalmologie des Quinze-Vingt Paris, France
View Trial Details
Completed

Open-Label, Dose-Escalating Study Assessing Safety, Tolerability, Efficacy, of RP103 in Mitochondrial Disease

NCT02023866

Conditions
Brain Diseases, Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, +40 more
Locations
  • University of California at San Diego (UCSD) San Diego, California, United States
  • Stanford University Stanford, California, United States
  • Akron Children's Hospital Akron, Ohio, United States
  • Baylor College of Medicine Houston, Texas, United States
View Trial Details

Related conditions