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Clinical trial condition

Muscular Atrophy, Spinal

Explore clinical trials studying Muscular Atrophy, Spinal. Study availability and eligibility vary by location and protocol.

218 public trials 50 recruiting studies
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Muscular Atrophy, Spinal trial results

Completed

An Open-label Safety, Tolerability and Dose-Range Finding Study of Multiple Doses of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy

NCT01703988

Conditions
Central Nervous System Diseases, Motor Neuron Disease, Muscular Atrophy, Spinal, +5 more
Locations
  • Boston Children's Hospital Boston, Massachusetts, United States
  • Columbia University Medical Center New York, United States
  • UT Southwestern Medical Center - Children's Medical Center Dallas Dallas, Texas, United States
  • University of Utah School of Medicine Salt Lake City, Utah, United States
View Trial Details
Completed

A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function

NCT03920865

Conditions
Central Nervous System Diseases, Motor Neuron Disease, Muscular Atrophy, Spinal, +4 more
Locations
  • Clinical Pharmacology of Miami, Inc. Miami, Florida, United States
  • Orlando Clinical Research Center Orlando, Florida, United States
  • American Research Corporation Inc. San Antonio, Texas, United States
View Trial Details
Completed

An Open-label Safety, Tolerability, and Dose-range Finding Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA)

NCT01494701

Conditions
Central Nervous System Diseases, Motor Neuron Disease, Muscular Atrophy, Spinal, +5 more
Locations
  • Children's Hospital Boston Boston, Massachusetts, United States
  • Columbia University Medical Center New York, United States
  • UT Southwestern Medical Center - Children's Medical Center Dallas Dallas, Texas, United States
  • University of Utah School of Medicine Salt Lake City, Utah, United States
View Trial Details
Completed

A Study to Assess the Efficacy, Safety and Pharmacokinetics of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy (SMA)

NCT01839656

Conditions
Central Nervous System Diseases, Motor Neuron Disease, Muscular Atrophy, Spinal, +5 more
Locations
  • Stanford University Medical Center Stanford, California, United States
  • Nemours Children's Hospital Orlando, Florida, United States
  • Columbia University Medical Center New York, United States
  • The Hospital for Sick Children (SickKids) Toronto, Ontario, Canada
View Trial Details
Completed

A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA)

NCT02292537

Conditions
Central Nervous System Diseases, Motor Neuron Disease, Muscular Atrophy, Spinal, +5 more
Locations
  • UCLA Clinical and Translational Research Center Los Angeles, California, United States
  • Lucile Packard Children's Hospital at Stanford Palo Alto, California, United States
  • Children's Hospital Colorado Aurora, Colorado, United States
  • Nemours Children's Hospital Orlando, Florida, United States
View all 24 locations
View Trial Details
Completed

An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in ISIS 396443-CS2 (NCT01703988) or ISIS 396443-CS10 (NCT01780246)

NCT02052791

Conditions
Central Nervous System Diseases, Motor Neuron Disease, Muscular Atrophy, Spinal, +5 more
Locations
  • Boston Children's Hospital Boston, Massachusetts, United States
  • Columbia University Medical Center New York, United States
  • UT Southwestern Medical Center - Children's Medical Center Dallas Dallas, Texas, United States
  • University of Utah School of Medicine Salt Lake City, Utah, United States
View Trial Details
Completed

An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy Who Previously Participated in ISIS 396443-CS1 (NCT01494701)

NCT01780246

Conditions
Central Nervous System Diseases, Motor Neuron Disease, Muscular Atrophy, Spinal, +5 more
Locations
  • Boston Children's Hospital Boston, Massachusetts, United States
  • Columbia University Medical Center New York, United States
  • UT Southwestern Medical Center - Children's Medical Center Dallas Dallas, Texas, United States
  • University of Utah School of Medicine Salt Lake City, Utah, United States
View Trial Details

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