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Li-Fraumeni Syndrome

Clinical trial condition

Li-Fraumeni Syndrome

Explore clinical trials studying Li-Fraumeni Syndrome. Study availability and eligibility vary by location and protocol.

22 public trials 11 recruiting studies

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Li-Fraumeni Syndrome trial results

Recruiting

Arsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Pediatric Cancer

NCT06088030

Conditions: Congenital, Hereditary, and Neonatal Diseases and Abnormalities, DNA Repair-Deficiency Disorders, Genetic Diseases, Inborn, +7 more
Locations: Sun Yat-sen Memorial Hospital, Sun Yat-sen University Guangzhou, Guangdong, China

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Enrolling by Invitation

Li-Fraumeni Syndrome Imaging Study

NCT03176836

Conditions: Congenital, Hereditary, and Neonatal Diseases and Abnormalities, DNA Repair-Deficiency Disorders, Genetic Diseases, Inborn, +5 more
Locations: The Hospital for Sick Children Toronto, Ontario, Canada

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Not Yet Recruiting

Clinical Genetics Branch Eligibility Screening Survey

NCT07005297

Conditions: Abnormalities, Multiple, Anemia, Anemia, Aplastic, +44 more
Locations: National Cancer Institute Rockville, Maryland, United States

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Completed

Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer

NCT00040222

Conditions: Adnexal Diseases, BRCA1-associate Malignancies, BRCA2-associated Malignancies, +42 more
Locations: National Institutes of Health Clinical Center Bethesda, Maryland, United States

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Completed

Exploring How to Adapt an Evidence-Based Mindful Self-Compassion Program for Young Adults With Li-Fraumeni Syndrome

NCT07032922

Conditions: Behavior, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, DNA Repair-Deficiency Disorders, +8 more
Locations: NCI Shady Grove Campus Rockville, Maryland, United States

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Completed

Phenotype and Prognosis of Patients With Breast Cancer and Pathogenic Variants of TP53

NCT04966923

Conditions: Breast Cancer, Breast Diseases, Breast Neoplasms, +13 more
Locations: ICESP São Paulo, Brazil

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Completed

Magnetic Resonance Imaging Screening in Li Fraumeni Syndrome

NCT01737255

Conditions: Congenital, Hereditary, and Neonatal Diseases and Abnormalities, DNA Repair-Deficiency Disorders, Genetic Diseases, Inborn, +5 more
Locations: Cancer Genetics Unit, Royal Marsden Hospital Sutton, Surrey, United Kingdom

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Completed

Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome

NCT00406445

Conditions: Carriers of p53 Mutation, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, DNA Repair-Deficiency Disorders, +8 more
Locations: National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States

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Completed

LIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome)

NCT01464086

Conditions: Congenital, Hereditary, and Neonatal Diseases and Abnormalities, DNA Repair-Deficiency Disorders, Genetic Diseases, Inborn, +6 more
Locations: Institut Gustave Roussy Villejuif, France

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Completed

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

NCT01981525

Conditions: Congenital, Hereditary, and Neonatal Diseases and Abnormalities, DNA Repair-Deficiency Disorders, Genetic Diseases, Inborn, +5 more
Locations: National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States

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Li-Fraumeni Syndrome

Li-Fraumeni Syndrome trial results

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