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Recruiting

Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)

NCT06891443

Conditions
Blindness, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, +28 more
Locations
  • UCSF Wayne and Gladys Valley Center for Vision San Francisco, California, United States
  • University of Miami - Bascom Palmer Eye Institute Miami, Florida, United States
  • University of Iowa Iowa City, Iowa, United States
  • University of Minnesota Medical School Minneapolis, Minnesota, United States
View all 17 locations
View Trial Details
Not Yet Recruiting

Safety and Tolerability of Subretinal OPGx-RDH12-1001 for LCA-Associated Inherited Retinal Degeneration (LCA-IRD)

NCT07681778

Conditions
Eye Diseases, Eye Diseases, Hereditary, Leber Congenital Amaurosis, +2 more
Locations
  • Associated Retina Consultants Phoenix, Arizona, United States
  • Perelman School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania, United States
  • Retina Consultants of Texas & Retina Group Inc. Houston, Texas, United States
View Trial Details
Completed

A Patient Registry Study for Patients Treated With Voretigene Neparvovec in US

NCT03597399

Conditions
Confirmed Biallelic RPE65 Mutation-associated Retinal Dystrophy, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Eye Diseases, +7 more
Locations
  • Children's Hospital of Los Angeles Los Angeles, California, United States
  • Bascom Palmer Eye Institute Miami, Florida, United States
  • University of Iowa Hospitals & Clinics Iowa City, Iowa, United States
  • Massachusetts Eye and Ear Institute Boston, Massachusetts, United States
View Trial Details
Completed

Natural History Study of CEP290-Related Retinal Degeneration

NCT03396042

Conditions
Blindness, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, +17 more
Locations
  • Bascom Palmer Eye Institute Miami, Florida, United States
  • Massachusetts Eye and Ear Infirmary Boston, Massachusetts, United States
  • W.K. Kellogg Eye Center Ann Arbor, Michigan, United States
  • Casey Eye Institute - OHSU Portland, Oregon, United States
View Trial Details
Completed

Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT

NCT02575430

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Eye Diseases, Eye Diseases, Hereditary, +8 more
Locations
  • Wilmer Eye Institute - Johns Hopkins Hospital Baltimore, Maryland, United States
  • Casey Eye Institute - Marquam Hill Portland, Oregon, United States
  • The Hospital for Sick Children, Ophthalmology and Vision Sciences Toronto, Ontario, Canada
  • Montreal Children's Hospital, McGill University Health Centre Montreal, Quebec, Canada
View Trial Details
Completed

Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis or Retinitis Pigmentosa (Extension of Study RET IRD 01)

NCT01521793

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Eye Diseases, Eye Diseases, Hereditary, +8 more
Locations
  • The Chicago Lighthouse (University of Illinois at Chicago, Pangere Center for Inherited Retinal Disease) Chicago, Illinois, United States
  • Wilmer Eye Institute (Johns Hopkins University) Baltimore, Maryland, United States
  • Montreal Children's Hospital, McGill University Health Centre Montreal, Quebec, Canada
  • Institute for Ophthalmic Research, University of Tubingen Tübingen, Germany
View Trial Details
Completed

Safety/Proof of Concept Study of Oral QLT091001 in Subjects With Leber Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP) Due to Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) Mutations

NCT01014052

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Eye Diseases, Eye Diseases, Hereditary, +8 more
Locations
  • The Chicago Lighthouse for People Who Are Blind or Visually Impaired (The Pangere Center For Inherited Retinal Diseases) Chicago, Illinois, United States
  • Wilmer Eye Institute (Johns Hopkins University) Baltimore, Maryland, United States
  • Scheie Eye Institute Philadelphia, Pennsylvania, United States
  • Montreal Children's Hospital, McGill University Health Centre Montreal, Quebec, Canada
View Trial Details
Active, Not Recruiting

Study to Assess the Safety and Efficacy of OCU400 for Retinitis Pigmentosa and Leber Congenital Amaurosis

NCT05203939

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Enhanced S-Cone Syndrome, Eye Diseases, +9 more
Locations
  • Associated Retina Consultants Phoenix, Arizona, United States
  • Ocugen Site 5 - University of California, San Diego (UCSD) - Shiley Eye Institute La Jolla, California, United States
  • Ocugen Site 3 - Bascom Palmer Eye Institute Miami, Florida, United States
  • Ocugen Site 6 - Emory University Atlanta, Georgia, United States
View Trial Details