You Are What You Eat: Food as a Risk Factor and a Treatment for Depression

The study will include a combination of in-person, at-home, and virtual activities over the course of ~21 days (contingent on scheduling, this duration may vary and particularly between in-person visits #1 and #2). Participants complete three in-lab visits, each followed by a week of remote data tasks (e.g., ecological momentary assessment, continuous glucose monitoring, and physical activity and sleep tracking (Fitbit)).

During in-lab visit #1, participants will complete questionnaires and interviews, have a continuous glucose monitor inserted, and will have body composition measurements taken (height, weight, Inbody scan). Participants will complete the remote tasks for the following week while eating their typical diet (i.e., baseline period).

During in-lab visit #2, participants will complete questionnaires, interviews, and body composition measurements (height, weight, Inbody scan). Participants are randomly assigned to a meal delivery (will receive two weeks of low UPF meals and nutrition guidance) or control (will receive some snacks and nutrition guidance) condition (i.e., dietary intervention period). Participants will complete the remote tasks for the following two weeks.

During in-lab visit #3, participants will complete questionnaires, interviews, and body composition measurements (height, weight, InBody scan).

Participants are contacted 1- and 6-months later to complete a short follow-up survey and provide information about their current diet.

Inclusion criteria

• 18+ years of age
• Must own an Android or iPhone smartphone
• Must be able to access phone one every 90 minutes
• Able to attend consent call over zoom or phone
• Endorsement of a PHQ-8 score of at least 10 assessed at consent
• Endorsement of a PHQ-8 score of at least 8 assessed 24 hours prior to Visit 1
• Endorse daily intake of at least UPF foods
• Willing to come to three in-lab visits
• Willing to follow dietary guidelines
• Must be able to speak, write, and read English fluently

Exclusion criteria

• Regular smoking of cigarettes or vaping of nicotine
• History of medication that impact reward, eating, or indicate severe mental health conditions (e.g., Lithium)
• The following medical conditions; Diabetes Type I, Diabetes Type II, Prediabetes, Bipolar Disorder, Schizophrenia, Psychotic Disorder, Depression with psychotic symptoms, Borderline Personality Disorder, Hypoglycemia, Substance use disorder (e.g., alcohol use disorder, opioid use disorder, cannabis use disorder), Obsessive compulsive disorder, and Post-traumatic stress disorder
• Endorsement of a suicide attempt or having been hospitalized for psychiatric reasons in the last year
• A diagnosis of a restrictive eating disorder (anorexia nervosa, bulimia nervosa, purging disorder) within the last 5 years
• History of disorders that impact eating (e.g., cancer, irritable bowel syndrome, inflammatory bowel disease, hypothyroidism).
• Current pregnancy, breast-feeding, trying to get pregnant, or within six months of having given birth
• Frequent (i.e., weekly) night shift work or irregular shifts and for abnormal sleep patterns (i.e., wake up time after 11am)