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Completed

NCT Number: NCT02679898

Whole Body Vibration and External Load Exercise Training on Cardiovascular and Autonomic Function in Obese Individuals

Obesity is directly related to arterial dysfunction and negatively associated to muscle strength. High-intensity resistance exercise is the favored modality to offset muscle weakness, yet, adverse effects on arterial function (pulse wave velocity, wave reflection, and aortic and brachial blood pressures) have been observed. Conventional unloaded-whole body vibration training (WBVT) has improved arterial function in overweight/obese women but appears to be low-intensity. Nevertheless, the effects of moderate-intensity (by adding external load) WBVT on arterial and muscle function are unknown. Therefore, the purpose of this study was to examine whether loaded-WBVT would induce greater benefits than unloaded-WBVT on arterial and muscle function in young overweight/obese women. Furthermore, we examined whether these changes were similar to healthy lean young women.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–25 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

FSU College of Human Sciences

Tallahassee, Florida, 32306, United States

About this study

The purpose of this study was to determine the effects of 6 weeks of loaded-WBVT on arterial stiffness, peripheral and aortic blood pressures, wave reflection, endothelial function, and muscle strength in overweight/obese women.

The specific aims of the study were:

  • To examine whether 6 weeks of loaded-WBVT was more beneficial than unloaded-WBVT in decreasing cardiovascular risk factors by assessing arterial stiffness (aortic, leg, and systemic), aortic blood pressures and wave reflection, brachial blood pressures, autonomic function, endothelial function, and blood flow (leg and arm).
  • To determine the extent to which 6 weeks of loaded-WBVT improved body composition measured by changes in fat and lean mass utilizing dual-energy x-ray absorptiometry and waist circumference.
  • To evaluate the effect of 6 wees of loaded-WBVT on muscle strength by using the one-repetition maximum test (leg press and chest press exercises).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female
  • 18 to 25 years of age
  • Sedentary (less than 120 min per wk)
  • 15 lean (Body mass index of 18-25 kg/m²)
  • 45 overweight/obese (Body mass index of 27-39.9 kg/m²)

Exclusion criteria

  • Younger than 18 or older than 25 years of age
  • Body mass index lower than 18 or higher than 39.9
  • Physically active or competitively active
  • Smokers
  • Pregnant
  • Irregular menstrual cycle
  • Use of dietary supplementations (e.g.,L-arginine,L-citrulline,antioxidants)
  • Any contraindications to exercise and/or whole-body vibration exercise

Treatment and study plan

Unloaded-Whole Body Vibration (WBVT)

Other

The unloaded-WBVT intervention consists of four leg exercises performed dynamically over a vibrating platform 3 times/week for 6 weeks. Dynamic movements were performed with controlled movements starting from an upright position into a 90 and 120 degree knee angle, wide-stance squat, and maximal heel elevation. The training volume increased progressively by increasing the intensity of the vibration (30-35 Hz; low-high amplitude), duration of exercise (30-60 sec), number of sets per exercise (2-8), and total during of training session, while decreasing the rest periods (60-30 sec).

Loaded-Whole Body Vibration (WBVT)

Other

The loaded-WBVT intervention consists of four leg exercises performed dynamically over a vibrating platform 3 times/week for 6 weeks. Importantly, an external load was applied to a weight vest to account for the necessary weight to perform a specific number of repetitions (progressed from 15-8 repetitions maximum during the 6 weeks). Dynamic movements were performed with controlled movements starting from an upright position into a 90 and 120 degree knee angle, wide-stance squat, and maximal heel elevation. The training volume increased progressively by increasing the intensity of the vibration (30-35 Hz; low-high amplitude), duration of exercise (30-60 sec), number of sets per exercise (2-8), and total during of training session, while decreasing the rest periods (60-30 sec).

Primary outcomes

  1. Arterial Stiffness

    Time frame: 6 weeks

    Aortic, leg, and systemic pulse wave velocity acquired through non-invasive sensors.

  2. Pressure Wave Reflection

    Time frame: 6 weeks

    Augmentation index acquired through radial tonometry.

Secondary outcomes

  1. Body Composition

    Time frame: 6 weeks

    Measuring fat mass and lean mass from dual-energy x-ray absorptiometry.

  2. Muscle Strength

    Time frame: 6 weeks

    Using one-repetition maximum (1-RM) test for the leg press and chest press exercises.

  3. Autonomic Function

    Time frame: 6 weeks

    Heart rate variability through electrocardiogram.

  4. Blood Pressures

    Time frame: 6 weeks

    Non-invasive measures of brachial and aortic blood pressures.

  5. Endothelial Function

    Time frame: 6 weeks

    Non-invasive arm and leg blood flow using vascular ultrasound positioned on my skin at rest and during increased blood flow.

Sponsors and collaborators

Lead sponsor

Florida State University

Other

Registry information

Official study title

The Effect of the Combination of Whole Body Vibration and External Load Exercise Training on Cardiovascular and Autonomic Function in Obese Individuals

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Feb 11, 2016
Registry last updated
Feb 11, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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