The Food Intake Phenotype: Assessing Eating Behavior and Food Preferences as Risk Factors for Obesity

The prevalence of obesity in the United States has reached alarming proportions with 33% of adults over the age of 20 being overweight. In some populations, obesity is even more prevalent. Although there have been a number of advances in our understanding of the genetics of obesity, the environmental influences on the genetic expression of obesity requires further investigation.

In an effort to understand some of the influences on the high prevalence of obesity, the present study was designed to investigate what drives how much people eat. More specifically, we will try to understand what drives food intake utilizing 1) questionnaires that assess eating behavior, 2) measurements in blood, urine or fat tissue, and 3) genotypic associations to investigate the various factors that control what and how much people eat. We will make these evaluations by assessing eating behavior, food preferences including usual fat intake and preferences for high fat foods, body image perceptions, and energy expenditure. It is hoped that the data gathered from this study will elucidate some of the risk factors for the development of obesity.

• Inclusion Criteria:

• Healthy, as determined by medical history, physical examination, and laboratory tests.
• 18-65 years old
• Non-diabetic status

Exclusion criteria

• Hypo- or hyper-thyroid
• Blood pressure greater than 160/95
• Cardiovascular disease
• Gallbladder disease
• Alcohol and/or current use of drugs (more than 2 drinks per day and regular use of drugs such as amphetamines, cocaine, or heroin)
• Psychiatric conditions or behavior that would be incompatible with safe and successful participation in this study, including claustrophobia and eating disorders such as anorexia or bulimia nervosa

• Use of medications affecting metabolism and appetite

• Pregnancy

• Current use of nicotine products, including tobacco, electronic cigarettes, and nicotine replacement therapies that exceed Very Low Dependence on the Fagerstr(SqrRoot)(Delta)m Test for Nicotine Dependence Tool (score greater than 2).

Subjects may be excluded or withdrawn from the study if they have any conditions not specifically mentioned above that may interfere with the collection of the food intake. This includes such issues as not following study and unit policies and procedures, diagnosis of contraindications following admission, and development of illness/infection unrelated to the study. For example, volunteers who do not comply with the vending machine protocol (i.e., share food, do not record what they eat, eat outside of room, etc) may be withdrawn from the study.