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Active, Not Recruiting

NCT Number: NCT00580996

Water and the Gastropressor Response - Tachyphylaxis

We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Orthostatic Hypotension Autonomic Nervous System Diseases Cardiovascular Diseases Hypotension Hypotension, Orthostatic Nervous System Diseases Orthostatic Intolerance Primary Dysautonomias Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Vanderbilt University

Nashville, Tennessee, 37232, United States

About this study

We are studying the effects of oral water ingestion in patients with orthostatic hypotension. This has been termed the Gastropressor Response. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16 oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will be given to start, with 16 oz again as the second dose.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • orthostatic hypotension (fall in BP>20/10 mmHg)
  • pressor response to water in other studies
  • Age 18-80 years

Exclusion criteria

  • pregnancy

Treatment and study plan

water high dose

Other

water 16 oz PO x 1

water tiny dose

Other

water 1 oz PO x 1

Primary outcomes

  1. blood pressure

    Time frame: 2nd water intervention

Secondary outcomes

  1. heart rate

    Time frame: 2nd intervention

Sponsors and collaborators

Lead sponsor

Satish R. Raj

Other

Registry information

Official study title

Water and the Gastropressor Response - Tachyphylaxis (Specific Aim 1.2)

Important dates

Study start
2006
Primary completion
2029
Study completion
2029
First posted
Dec 27, 2007
Registry last updated
Oct 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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