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Active, Not Recruiting

NCT Number: NCT00581373

Water and the Gastropressor Response - Diurnal Variability

We will test the null hypothesis that there is no diurnal (morning to afternoon)variability in the blood pressure response to the ingestion of water 16 oz.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Orthostatic Hypotension Autonomic Nervous System Diseases Cardiovascular Diseases Hypotension Hypotension, Orthostatic Nervous System Diseases Orthostatic Intolerance Primary Dysautonomias Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Vanderbilt University

Nashville, Tennessee, 37232, United States

About this study

We will test the null hypothesis that there is no diurnal (morning to afternoon)variability in the blood pressure response to the ingestion of water 16 oz. This will involve having participants ingest 16 oz water rapidly in the morning and in the afternoon.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • orthostatic intolerance

Exclusion criteria

  • pregnancy

Treatment and study plan

water 16 fl oz

Other

water 16 fl oz in AM and repeat in late afternoon

Primary outcomes

  1. blood pressure

    Time frame: 1 day

    peak systolic blood pressure within 60 min of ingestion

Secondary outcomes

  1. heart rate

    Time frame: 1 day

    heart rate at peak BP within 60 min of ingestion

Sponsors and collaborators

Lead sponsor

Satish R. Raj

Other

Registry information

Official study title

Water and the Gastropressor Response - Diurnal Variability (Specific Aim 1.3)

Important dates

Study start
2007
Primary completion
2029
Study completion
2029
First posted
Dec 27, 2007
Registry last updated
Oct 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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